Intragastric balloon for "non-morbid" obesity:: A retrospective evaluation of tolerance and efficacy
Intragastric balloon for "non-morbid" obesity:: A retrospective evaluation of tolerance and efficacy
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DOI：
10.1381/096089204323013587
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发表时间：
2004-04-01
期刊：
影响因子：
2.9
通讯作者：
Benchetrit, S
中科院分区：
文献类型：
--
作者：
Roman, S;Napoléon, B;Benchetrit, S
背景：胃内球囊的一个潜在适应症是减轻轻度至中度肥胖的体重。作者回顾性评价了BioEnterics（R）胃内球囊（BIB）的耐受性和有效性。方法：从1998年2月至2001年7月，在内窥镜控制下对176例患者（平均BMI 31 kg/m2）放置胃内球囊。在前142名患者中填充500 ml盐水，在后34名患者中填充600 ml盐水。在球囊插入后4至6个月内取出球囊。失访13例（7.4%）。113例患者（64.2%）在内窥镜下进行了取出，其中1例为气管抽吸。49例患者的球囊排空是自发的。1例BIB因小肠梗阻在腹腔镜手术中取出。副作用为：第一周内呕吐（90%），偶尔呕吐>3周（18%），低钾血症（8.5%），功能性肾衰竭（1.1%），腹痛（12.5%），胃食管反流（11.5%）。有2例胃溃疡，1例经内镜治疗的亚闭塞，1例经手术治疗的小肠梗阻，发生在所有病例的理论切除日期之后。平均额外体重减轻为38 ± 28.5%（500 ml球囊为35.4 ± 27.3%，600 ml球囊为48.8 ± 31.0%（P < 0.02））。结论：BIB在制造商规定的时间内取出似乎是安全的。其在非病态肥胖患者中减轻体重的功效可能部分取决于充盈体积。
Background: One potential indication for intra-gastric balloon is weight reduction for mild to moderate obesity. The authors evaluated retrospectively the tolerance and efficacy of the BioEnterics(R) intragastric balloon (BIB).Methods: From February 1998 to July 2001, an intragastric balloon was placed under endoscopic control in 176 patients (mean BMI 31 kg/m(2)). It was filled with 500 ml saline in the first 142 patients and with 600 ml in the last 34. Removal was proposed between 4 and 6 months after balloon insertion.Results: Balloon placement was uneventful. 13 patients were lost of follow-up (7.4%). Removal was performed endoscopically in 113 patients (64.2%), with 1 case of tracheal aspiration. Balloon evacuation was spontaneous in 49 cases. 1 BIB was removed at laparoscopic surgery for small bowel obstruction. Side-effects were: vomiting during the first week (90%), occasional vomiting for >3 weeks (18%), hypokalemia (8.5%), functional renal failure (1.1%), abdominal pain (12.5%), gastro-esophageal reflux (11.5%). There were 2 gastric ulcers, 1 sub-occlusion treated endoscopically and the 1 small bowel obstruction treated surgically, occurring after the theoretical date of removal in all cases. Mean excess weight loss was 38 +/- 28.5% (35.4 +/- 27.3% for 500-ml balloons and 48.8 +/- 31.0% for 600-ml balloons (P < 0.02)).Conclusions: The BIB appears to be safe provided that it is removed within the period specified by the manufacturer. Its efficacy to reduce weight in patients with non-morbid obesity may depend in part on the filling volume.