Red/green opponency in the rhesus macaque ERG spectral sensitivity is reduced by bicuculline.
Red/green opponency in the rhesus macaque ERG spectral sensitivity is reduced by bicuculline.
复制标题
荷包牡丹碱降低了恒河猴 ERG 光谱敏感性中的红/绿对立。
DOI：
10.1017/s0952523800000286
复制
发表时间：
1990
影响因子：
1.9
通讯作者：
Sperling,HG
中科院分区：
文献类型：
--
作者：
Mills,SL;Sperling,HG
在注射荷包牡丹碱、士的宁或不注射药物后，从恒河猴ERG的a-、B-和d-波推导出光谱敏感性曲线。在没有药物注射的情况下，a-和d-波曲线通过加权光感受器吸收光谱的加性模型拟合良好，而B-波曲线需要抑制项才能产生足够的拟合。荷包牡丹碱，但不是士的宁，减少了重量分配给抑制条款的剂量依赖性的方式，到一个点，没有抑制是明显的。结果表明，GABA能突触是灵长类双极细胞表达红/绿色颜色一致性所必需的。
Spectral-sensitivity curves were derived from the a−, b−, and d−waves of rhesus monkey ERGs after injection of bicuculline, strychnine, or no drug. Without drug injection, the a− and d−wave curves were well-fit by an additive model of weighted photoreceptor absorption spectra, while the b−wave curve requires inhibitory terms to produce an adequate fit. Bicuculline, but not strychnine, reduced the weight assigned to the inhibitory terms in a dose-dependent fashion, to the point that no inhibition was evident. The results suggest that GABAergic synapses are required for the expression of red/green color opponency in primate bipolar cells.