TESTING COMPUTER-CONTROLLED INFUSION PUMPS BY SIMULATION
TESTING COMPUTER-CONTROLLED INFUSION PUMPS BY SIMULATION
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DOI：
10.1097/00000542-198802000-00013
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发表时间：
1988-02-01
期刊：
影响因子：
8.8
通讯作者：
SCOTT, JC
中科院分区：
文献类型：
--
作者：
SHAFER, SL;SIEGEL, LC;SCOTT, JC
静脉麻醉药物的药代动力学行为可用二室或三室模型描述。要快速实现和维持这些药物的稳定血药浓度，需要一个复杂的给药方案，也许最好是由计算机控制。作者从描述隔室间药物转移的微分方程式出发，发展了一种模拟计算机控制输液泵性能的方法。他们还利用欧拉的S数值方法导出了这些方程的一个数学上简单而灵活的近似解。他们将这种近似的溶液合并到计算机控制的静脉药物输液泵中。他们通过模拟给一名假想的患者服用芬太尼来测试他们的泵，该患者的芬太尼药代动力学符合三室模型。精确的解析解作为比较的标准。在模型更新之间使用15-S间隔的近似技术，最大误差为0.25ng.cntdot。Ml-1，并迅速收敛于精确解。模拟显示了系统中的振荡。作者建议，在对这些设备进行临床试验之前，可以使用这种模拟来评估计算机控制的输液泵。
The pharmacokinetic behavior of intravenous anesthetic drugs can be described by two- or three-compartment models. Rapid achievement and maintenance of steady plasma concentrations of these drugs requires a complicated delivery scheme, perhaps best controlled by a computer. The authors developed a method of simulating the performance of a computer-controlled infusion pump from the differential equations describing drug transfer between compartments. They also derived a mathematically simple and flexible approximate solution to these equations using Euler''s numerical method. They incorporated this approximate solution into a computer-controlled infusion pump for intravenous drugs. They tested their pump by simulating the administration of fentanyl to a hypothetical patient whose fentanyl pharmacokinetics were described by a three-compartment model. The exact analytical solution served as the standard of comparison. The approximation technique, using a 15-s interval between model updates, had a maximum error of 0.25 ng .cntdot. ml-1, and rapidly converged on the exact solution. The simultations revealed oscillations in the system. The authors suggest that such simulations be used to evaluate computer-controlled infusion pumps prior to clinical trials of these devices.