The metabolic significance of protein-bound iodine of plasma; a study of its concentration under various conditions and of its rate of formation as measured with radioactive iodine.
The metabolic significance of protein-bound iodine of plasma; a study of its concentration under various conditions and of its rate of formation as measured with radioactive iodine.
复制标题
血浆蛋白结合碘的代谢意义；
DOI：
10.1210/endo-40-1-47
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发表时间：
1947
期刊：
影响因子：
4.8
通讯作者：
W. O. Reinhardt
中科院分区：
文献类型：
--
作者：
I. Chaikoff;A. Taurog;W. O. Reinhardt
血浆碘中的“蛋白结合”部分是指在加热条件下，钨酸、氢氧化锌或乙酸等试剂使血浆中的碘与蛋白质一起沿着沉淀出来，而且不能通过简单的洗涤从这些蛋白质中分离出来。尽管对这一级分的化学特性还知之甚少，但其在血浆中的浓度已被广泛用作人体甲状腺活性的指标（Salter等人，1941年; Man等人，1942; Lowenstein等人，1944;塔尔博特等人，1944年; Chaney，未发表的观察）。在本研究中，试图确定血浆蛋白结合碘的代谢意义。研究了在完全丧失甲状腺组织的大鼠以及在诱发甲状腺机能亢进的大鼠和豚鼠中其血浆浓度。使用放射性碘（I131）作为标记剂也使得研究蛋白质结合碘在两种状态下的形成速率成为可能。
THE FRACTION of plasma iodine designated “protein-bound” is the iodine that is precipitated from plasma along with its proteins by such agents as tungstic acid, zinc hydroxide, or acetic acid in the presence of heat and in addition cannot be freed from these proteins by simple washing. Although the chemical identity of this fraction is as yet poorly understood, its concentration in plasma has gained wide use as an indicator of thyroid activity in man. (Salter et al., 1941; Man et al., 1942; Lowenstein et al., 1944; Talbot et al., 1944; Chaney, unpublished observations). In the present investigation, an attempt has been made to determine the metabolic significance of plasma protein-bound iodine. Its concentration in plasma was studied in rats shown to be completely deprived of thyroid tissue and in rats and guinea pigs in which hyperthyroidism had been induced. The use of radioactive iodine (I131) as a labeling agent also made possible a study of the rate of formation of protein-bound iodine in both states...