Premature coronary-artery atherosclerosis in systemic lupus erythematosus
Premature coronary-artery atherosclerosis in systemic lupus erythematosus
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DOI：
10.1056/nejmoa035611
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发表时间：
2003-12-18
影响因子：
158.5
通讯作者：
Stein, CM
中科院分区：
文献类型：
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作者：
Asanuma, Y;Oeser, A;Stein, CM
背景：早发性冠状动脉疾病是系统性红斑狼疮患者发病和死亡的主要原因，但对冠状动脉粥样硬化的患病率、程度和病因知之甚少。方法：我们使用电子束计算机断层扫描筛查65例系统性红斑狼疮患者（平均[+/-SD]年龄，40.3+/-11.6岁）和69例无冠状动脉疾病史的对照组（平均年龄，42.7+/-12.6岁）冠状动脉钙化的存在。当检测到钙化时，通过Agatston评分测量其程度。比较患者与对照组冠状动脉疾病危险因素发生频率，探讨患者临床特征与冠状动脉钙化有无关系。结果：两组患者在年龄、种族和性别方面相似。狼疮患者冠状动脉钙化发生率（65例中有20例）高于对照组（69例中有6例）（P=0.002）。患者的平均钙化评分为68.9+/-244.2分，8.8+/-41.8分(P
BACKGROUND: Premature coronary artery disease is a major cause of illness and death in patients with systemic lupus erythematosus, but little is known about the prevalence, extent, and causes of coronary-artery atherosclerosis.METHODS: We used electron-beam computed tomography to screen for the presence of coronary-artery calcification in 65 patients with systemic lupus erythematosus (mean [+/-SD] age, 40.3+/-11.6 years) and 69 control subjects (mean age, 42.7+/-12.6 years) with no history of coronary artery disease. When calcification was detected, the extent was measured by means of the Agatston score. The frequency of risk factors for coronary artery disease was compared in patients and controls, and the relation between the patients' clinical characteristics and the presence or absence of coronary-artery calcification was examined.RESULTS: The two groups were similar with respect to age, race, and sex. Coronary-artery calcification was more frequent in patients with lupus (20 of 65 patients) than in control subjects (6 of 69 subjects) (P=0.002). The mean calcification score was 68.9+/-244.2 in the patients and 8.8+/-41.8 (P