Effects of exercise training on glucose homeostasis
Effects of exercise training on glucose homeostasis
复制标题
DOI：
10.2337/diacare.28.1.108
复制
发表时间：
2005-01-01
期刊：
影响因子：
16.2
通讯作者：
Bouchard, C
中科院分区：
文献类型：
--
作者：
Boulé, NG;Weisnagel, SJ;Bouchard, C
目的-为了确定健康的，以前久坐的参与者对来自静脉内葡萄糖耐量试验（IVGTT）的措施，为期20周的耐力训练计划的效果。研究设计和方法-在316名女性和280名男性（173名黑人和423名白人）的标准化训练计划之前和之后进行IVGTT。参与者每周在自行车测力计上锻炼3天，共60次。运动强度逐渐增加，从55%Vo（2 max），每次30分钟，到75%Vo（2 max），每次50分钟，结果-平均胰岛素敏感性增加了10%（P < 0.001）的干预后，但变化的变异性很高。男性比女性有更大的改善（P = 0.02）。空腹胰岛素的改善是暂时的，在最后一次运动后72小时消失。葡萄糖消失指数（3%，P = 0.02）和葡萄糖有效性（11%，P < 0.001）也有显著的平均增加，分别是葡萄糖耐量和葡萄糖调节自身处理能力的指标。在基线糖耐量最低的四分位数中，对葡萄糖的急性胰岛素反应（一种胰岛素分泌的测量）增加了7%，而在基线糖耐量最高的四分位数中减少了14%（P < 0.001）。IVGTT期间低于空腹水平的血糖区域减少了7%（P = 0.02）。结论-虽然结构化的定期运动的影响是高度可变的，但几乎所有IVGTT衍生变量都有改善。在没有实质性体重减轻的情况下，需要定期锻炼以持续改善葡萄糖稳态。
OBJECTIVE - To determine the effect of a 20-week endurance training program in healthy, previously sedentary participants on measures derived from an intravenous glucose tolerance test (IVGTT).RESEARCH DESIGN AND METHODS- An IVGTT was performed before and after a standardized training program in 316 women and 280 men (173 blacks and 423 whites). Participants exercised on cycle ergometers 3 days per week for 60 sessions. The exercise intensity was progressively increased from 55% Vo(2max) for 30 min per session to 75% Vo(2max) for 50 min per session.RESULTS- Mean insulin sensitivity increased by 10% (P < 0.001) following the intervention, but the variability in the changes was high. Men had larger improvements than women (P = 0.02). Improvements in fasting insulin were transitory, disappearing 72 h after the last bout of exercise. There were also significant mean increases in the glucose disappearance index (3%, P = 0.02) and in glucose effectiveness (11%, P < 0.001), measures of glucose tolerance and of the capacity of glucose to mediate its own disposal, respectively. The acute insulin response to glucose, a measure of insulin secretion, increased by 7% in the quartile with the lowest baseline glucose tolerance and decreased by 14% in the quartile with the highest baseline glucose tolerance (P < 0.001). The glucose area below fasting levels during the IVGTT was reduced by 7% (P = 0.02).CONCLUSIONS- Although the effects of structured regular exercise were highly variable, there were improvements in virtually all IVGTT-derived variables. In the absence of substantial weight loss, regular exercise is required for sustained improvements in glucose homeostasis.