Use of glucose solution for the alleviation of gemcitabine-induced vascular pain: a double blind randomized crossover study.
Use of glucose solution for the alleviation of gemcitabine-induced vascular pain: a double blind randomized crossover study.
复制标题
使用葡萄糖溶液缓解吉西他滨引起的血管疼痛：双盲随机交叉研究。
DOI：
10.1007/s00520-013-1901-9
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发表时间：
2013
影响因子：
3.1
通讯作者：
Yanagihara K.
中科院分区：
文献类型：
--
作者：
Nagai H;Kitano T;Nishimura T;Yasuda H;Nakata K;Takashima S;Kanai M;Matsumoto S;Mori Y;Kakudo Y;Sato H;Yamaguchi T;Kameno K;Kim YH;Mishima M;Yanagihara K.
目的吉西他滨广泛用于多种癌症的化疗。然而，血管疼痛经常发生在其输注过程中，这可能严重到足以导致治疗中断。进行这项研究，以确定是否溶解与5%的葡萄糖溶液将缓解血管疼痛相比，批准使用生理盐水作为diluting.MethodsPatients与癌症谁是每周吉西他滨治疗是合格的。在一项双盲、随机交叉研究中，在连续两次给药期间评估血管疼痛。一组计划接受溶于生理盐水的吉西他滨，然后接受溶于5%葡萄糖溶液的吉西他滨。在另一组中，5%葡萄糖溶液随后是生理盐水。主要终点是每种溶剂的总输注的血管疼痛的频率和次要终点的强度，作为一个视觉模拟量表和血管pain. ResultsEighty的持续时间进行评估，随机分配到每个治疗方案。与生理盐水相比，5%葡萄糖溶液的血管疼痛频率显著较低（40%对63%;p< 0.001）。与生理盐水相比，5%葡萄糖溶液的血管疼痛强度也降低（平均值，1.3分vs 2.7分;p< 0.001）。5%葡萄糖溶液和生理盐水溶液组之间的血管疼痛持续时间无显著统计学差异（平均值，21与18分钟;p= 0.420）。
PurposeGemcitabine is widely used for chemotherapy in many types of cancers. However, vascular pain frequently occurs during its infusion, which can be serious enough to cause treatment discontinuation. This study was conducted to determine whether dissolution with 5 % glucose solution would relieve vascular pain compared with the approved use of saline as the diluent.MethodsPatients with cancer who were treated with weekly gemcitabine were eligible. Vascular pain was assessed during two consecutive administrations in a double-blind, randomized crossover study. One group was scheduled to receive gemcitabine dissolved in saline followed by gemcitabine in 5 % glucose solution. In the other group, 5 % glucose solution was followed by saline. The primary endpoint was frequency of vascular pain for the total infusions of each solvent and the secondary endpoints were intensity, as assessed on a visual analogue scale and duration of vascular pain.ResultsEighty-seven patients were randomly assigned to each treatment schedule. Frequency of vascular pain was significantly lower with 5 % glucose solution compared with saline (40 versus 63 %;p< 0.001). The intensity of vascular pain was also reduced with 5 % glucose solution compared with saline (mean, 1.3 versus 2.7 points;p< 0.001). There was no significant statistical difference in duration of vascular pain between the 5 % glucose solution and saline solution groups (mean, 21 versus 18 min;p= 0.420).ConclusionsThe use of 5 % glucose solution to dissolve gemcitabine significantly reduced the frequency and the intensity of vascular pain compared with the use of saline.