Influence of environmental factors on IgE production.
Influence of environmental factors on IgE production.
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环境因素对 IgE 产生的影响。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
T. Miyamoto
中科院分区：
文献类型：
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作者：
S. Takafuji;S. Suzuki;M. Muranaka;T. Miyamoto
特应性疾病的流行似乎迅速增加，特别是在工业化国家。这一增长可能是由于某些环境因素的变化。本文主要探讨环境因素对IgE产生的影响。流行病学或实验报告表明，烟草烟雾、病毒感染和氯化汞可增强IgE的产生。我们证明了柴油机排气颗粒物（DEP），这似乎增加了城市环境中，IgE抗体的生产的增强作用。腹腔注射抗原与DEP混合免疫的小鼠的IgE抗体应答高于单独用抗原免疫的动物。DEP还具有通过呼吸道进入后在小鼠中产生IgE抗体的佐剂活性（自然进入模式）。即使以三周的间隔鼻内给予小剂量如1微克DEP，也证明了DEP对IgE抗体应答的增强作用。我们的进一步研究表明，悬浮颗粒物，包括DEP以外的材料，对IgE抗体的产生具有佐剂活性。
The prevalence of atopic diseases appears to have increased rapidly, especially in industrialized countries. The increase may be explained by a change in certain environmental factors. This article focuses on the influence of environmental factors on IgE production. Epidemiological or experimental reports have shown that tobacco smoke, virus infection and mercuric chloride may enhance IgE production. We demonstrated the enhancing effect of diesel-exhaust particulates (DEP), which seem to have increased in urban environments, on IgE antibody production. The IgE antibody responses in mice immunized by intraperitoneal injection of antigens mixed with DEP were higher than those in animals immunized with the antigens alone. DEP also had an adjuvant activity for IgE antibody production in mice after entry via the respiratory tract (the natural mode of entry). The enhancing effect of DEP on IgE antibody responses was demonstrated even when a small dose such as 1 micrograms of DEP was given intranasally at three-week intervals. Our further study has indicated that suspended particulate matter including materials other than DEP has an adjuvant activity for IgE antibody production.