Neural correlates of stimulus-reward association in the rat mediodorsal thalamus
Neural correlates of stimulus-reward association in the rat mediodorsal thalamus
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DOI：
10.1097/wnr.0b013e3280bef9a6
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发表时间：
2007-05-07
期刊：
影响因子：
1.7
通讯作者：
Ono, Taketoshi
中科院分区：
文献类型：
--
作者：
Kawagoe, Takashi;Tamura, Ryoi;Ono, Taketoshi
神经活动记录从行为大鼠的丘脑背内侧核的嗅觉线索与或没有奖励的歧视。大约10%的丘脑背侧神经元在提示过程中表现出明显的反应。这些神经元中的大多数对与奖励相关的线索做出强烈反应。这些神经元也区分线索，即使在同一个强化（奖励/非奖励）组。所有在灭绝、再学习和/或新学习试验中测试的神经元都根据奖励偶然性灵活地改变了它们的反应。这些神经元主要位于中央和内侧段的背内侧丘脑。这些结果表明，这些丘脑背侧神经元是嗅觉刺激与奖赏的联想学习的神经基质。
Neural activity was recorded from the mediodorsal thalamic nucleus of behaving rats during the discrimination of olfactory cues associated with or without a reward. Approximately 10% of medioclorsal thalamic neurons showed significant responses during the presentation of cues. Most of these neurons responded strongly to cues associated with a reward. These neurons also differentiated between cues, even in the same reinforcement (reward/nonreward) group. All of the neurons tested in extinction, relearning, and/or new-learning trials changed their responses flexibly according to the reward contingency. These neurons were located primarily in the central and medial segments of the mediodorsal thalamus. These results suggest that these medioclorsal thalamic neurons are the neural substrates for association learning of olfactory stimuli with rewards.