Exercise training augments regional bone and marrow blood flow during exercise.
Exercise training augments regional bone and marrow blood flow during exercise.
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DOI：
10.1249/mss.0000000000000342
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发表时间：
2014-11
影响因子：
4.1
通讯作者：
Delp MD
中科院分区：
文献类型：
--
作者：
Stabley JN;Moningka NC;Behnke BJ;Delp MD
在跑台运动训练后，大鼠股骨的主要营养动脉显示一氧化氮介导的血管舒张增加。本研究旨在确定运动训练是否改善了休息时和运动时后肢骨和骨髓的血流分布。对6 - 8月龄雄性Sprague-Dawley大鼠进行运动训练（ET），在10-12周的时间内以15 m/min的速度在15°斜面上跑步机行走60 min/d。在血流量测量前一周内，使久坐（SED）对照动物适应跑步机运动5 min/d。使用参考样品微球方法，在休息和低强度运动（15 m/min步行，0°倾斜）期间测定股骨、胫骨和腓骨9个不同区域的血流量。结果表明，增加运动充血以上，观察到在SED大鼠在运动过程中，只有一个区域的骨，ET大鼠的股骨骨干。然而，虽然运动充血发生在3的9个后肢骨区域测量在SED大鼠，运动充血发生在7的9个区域在ET大鼠。这些数据表明，在一段时间的运动训练后的体力活动中，广义后肢骨和骨髓血流量增加。训练后局部骨和骨髓血流量的升高可能会增加髓压和骨间质液流量，从而有利于骨的完整性。
The principal nutrient artery to the femur demonstrates an increase in nitric oxide mediated vasodilation in rats after treadmill exercise training. The present study sought to determine whether exercise training improves hindlimb bone and marrow blood flow distribution at rest and during exercise. Six-eight month old male Sprague-Dawley rats were exercise trained (ET) with treadmill walking at 15 m/min up a 15° incline for 60 min/d over a 10–12 wk period. Sedentary (SED) control animals were acclimated to treadmill exercise for 5 min/d during the week preceding the blood flow measurements. Blood flow to nine distinct regions of the femur, tibia, and fibula were determined at rest and during low-intensity exercise (15 m/min walking, 0° incline) using the reference sample microsphere method. The results demonstrate an augmentation of exercise hyperemia above that observed in SED rats during exercise in only one region of bone, the femoral diaphysis of ET rats. However, while exercise hyperemia occurred in 3 of the 9 hindlimb bone regions measured in SED rats, exercise hyperemia occurred in 7 of 9 regions in ET rats. These data indicate an increase in generalized hindlimb bone and marrow blood flow during physical activity following a period of exercise training. Elevations in regional bone and marrow blood flow after training may augment medullary pressure and bone interstitial fluid flow, thus benefiting bone integrity.