Sex differences in pain perception and anxiety. A psychophysical study with topical capsaicin
Sex differences in pain perception and anxiety. A psychophysical study with topical capsaicin
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DOI：
10.1016/j.pain.2003.11.017
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发表时间：
2004-04-01
期刊：
影响因子：
7.4
通讯作者：
Bushnell, MC
中科院分区：
文献类型：
--
作者：
Frot, M;Feine, JS;Bushnell, MC
许多证据表明，女性经历的痛苦刺激比男性更强烈。然而，一些数据表明，持续的低度疼痛对男性来说可能比对女性更令人不安。目前的实验通过比较不同性别辣椒素引起的疼痛的感觉和情感方面，评估了疼痛对男性比女性更令人不安的假设。 10 名男性和 10 名女性（年龄 20-46 岁）在一次疗程中接受局部辣椒素治疗，每次 30 分钟，并在另一疗程中接受脚踝治疗。受试者根据视觉模拟量表对施用辣椒素期间每分钟以及去除辣椒素后 30 分钟内的疼痛强度、不愉快和焦虑程度进行评分。在使用辣椒素期间，女性对疼痛强度（P = 0.04）和不愉快感（P = 0.05）的评价均高于男性。此外，尽管物理刺激相同，但受试者对面部疼痛强度和不适的评价高于脚踝。尽管疼痛等级较低，但男性比女性报告更多与疼痛相关的焦虑（P = 0.02）。此外，男性的焦虑与疼痛强度和不愉快感之间表现出显着的正相关，而女性则没有。去除辣椒素后，性别对残留感觉的强度（P = 0.18）或不愉快（P = 0.37）没有总体影响。然而，男性的焦虑程度与感觉的强度和不愉快程度仍然呈正相关。我们的数据通过局部辣椒素模型证实，女性对疼痛的评价高于男性，但尽管男性的疼痛评价较低，但与疼痛相关的焦虑更多。 (C) 2003 年国际疼痛研究协会。由 Elsevier B.V. 出版。保留所有权利。
Much evidence indicates that women experience painful stimuli as more intense than men do. Nevertheless, some data suggest that sustained low-level pain may be more disturbing to men than to women. The current experiment evaluated the hypothesis that pain is more disturbing for men than for women by comparing across genders sensory and emotional aspects of pain evoked by capsaicin. Ten men and 10 women (aged 20-46 years) received topical capsaicin for 30 min on the face in one session and on the ankle in another. The subjects rated on visual analog scales pain intensity, unpleasantness and anxiety each minute during capsaicin application and for 30 min after its removal. During capsaicin application, females rated both pain intensity (P = 0.04) and unpleasantness (P = 0.05) higher than did males. Further, subjects rated pain intensity and unpleasantness higher on the face than on the ankle, although the physical stimulus was the same. Despite their lower pain ratings, men reported more pain-related anxiety than women (P = 0.02). Moreover, men showed a significant positive correlation between anxiety and pain intensity and unpleasantness, whereas women did not. After removing the capsaicin, there was no overall effect of sex on either intensity (P = 0.18) or unpleasantness (P = 0.37) of the residual sensation. However, men still showed a positive correlation between anxiety and the intensity and unpleasantness of the sensation. Our data confirm with the topical capsaicin model that women rate pain higher than men, but despite their lower pain ratings, males have more anxiety related to pain. (C) 2003 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.