H2O2-Induced Decomposition of Layer-by-Layer Films Consisting of Phenylboronic Acid-Bearing Poly(allylamine) and Poly(vinyl alcohol)
H2O2-Induced Decomposition of Layer-by-Layer Films Consisting of Phenylboronic Acid-Bearing Poly(allylamine) and Poly(vinyl alcohol)
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DOI：
10.1021/la501750s
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发表时间：
2014-08-12
期刊：
影响因子：
3.9
通讯作者：
Anzai, Jun-ichi
中科院分区：
文献类型：
--
作者：
Sato, Katsuhiko;Takahashi, Mao;Anzai, Jun-ichi
通过在石英载玻片表面交替沉积含苯基硼酸的聚烯丙胺盐酸盐 (PBA-PAH) 和聚乙烯醇 (PVA) 来制备逐层 (LbL) 薄膜，以形成可响应过氧化氢 (H2O2) 分解的薄膜。 PBA-PAH/PVA薄膜在H2O2存在下分解；分解的程度和动力学取决于 H2O2 的浓度和溶液的 pH 值。例如，在pH 7.4的1.0 mM H2O2溶液中，薄膜在30分钟内完全分解，而在0.1 mM H2O2溶液中则需要180分钟。 H2O2 引起的薄膜分解可以用 PBA-PAH 链中 PBA 残基中碳硼键的氧化断裂来解释。建议将 PBA-PAH/PVA 薄膜用于开发 H2O2 敏感的输送系统。
Layer-by-layer (LbL) films were prepared by an alternate deposition of phenylboronic acid-bearing poly(allylamine hydrochloride) (PBA-PAH) and poly(vinyl alcohol) (PVA) on the surface of a quartz slide to develop thin films that can be decomposed in response to hydrogen peroxide (H2O2). The PBA-PAH/PVA films decomposed in the presence of H2O2; the degree and kinetics of decomposition depend on the concentration of H2O2 and on the pH of the solution. For example, the film decomposition completely occurred in 30 min in 1.0 mM H2O2 solution at pH 7.4, while it took 180 min in 0.1 mM H2O2 solution. The H2O2-induced decomposition of the film can be explained in terms of the oxidative scission of the carbon-boron bond in PBA residues in the PBA-PAH chains. A potential use of the PBA-PAH/PVA films in developing H2O2-sensitive delivery systems was suggested.