Modulation of feedback related activity in the rostral anterior cingulate cortex during trial and error exploration
Modulation of feedback related activity in the rostral anterior cingulate cortex during trial and error exploration
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DOI：
10.1016/j.neuroimage.2012.06.023
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发表时间：
2012-11-15
期刊：
影响因子：
5.7
通讯作者：
Petrides, Michael
中科院分区：
文献类型：
--
作者：
Amiez, Celine;Sallet, Jerome;Petrides, Michael
本功能磁共振成像（fMRI）实验的目的是澄清的喙前扣带皮层（rACC）在确定性环境中的反馈评价的作用。我们测试，特别是，反应的rACC检测不同类型的反馈，并对不同水平的预期结果。我们使用了一个解决问题的任务中，受试者必须发现，在连续的试验中，其中一个四个呈现的刺激是与积极的反馈，其他的与错误反馈。在这个任务中，两个阶段交替进行：1。一个探索期，其中错误反馈指示适当地调整随后的反应（并继续探索），并且第一个正反馈指示改变策略（即从探索行为转变为剥削行为），以及2.受试者必须重复正确选择的剥削期。rACC是在探索期对错误和第一次正确的正反馈进行分析时招募的。此外，rACC活性受到正奖励预测误差值（即获得的反馈与预期反馈之间的差异）的调节。总之，这些结果揭示了关键作用的rACC的学习最佳策略的显着反馈的评价。(C)2012 Elsevier Inc. All rights reserved.
The present functional magnetic resonance imaging (fMRI) experiment aims at clarifying the role of the rostral anterior cingulate cortex (rACC) in the evaluation of feedback in a deterministic environment. We tested, in particular, the response of the rACC to the detection of different types of feedback, and to varying levels of outcome expectancy. We used a problem-solving task in which subjects had to discover, in successive trials, which one of the four presented stimuli was associated with a positive feedback, the other ones being associated with error feedback. In this task, two periods alternated: 1. an exploratory period in which error feedback indicated to adapt the following response appropriately (and continue to explore), and first positive feedback indicated to change strategy (i.e. to shift from explorative to exploitative behavior), and 2. an exploitative period in which subjects had to repeat the correct choice. The rACC is recruited in the exploratory period during the analysis of both error and first correct positive feedback. In addition, the rACC activity was modulated by positive reward prediction error values (i.e. the difference between obtained and expected feedback). Altogether, these results reveal the critical role of the rACC in the evaluation of salient feedback for learning optimal strategies. (C) 2012 Elsevier Inc. All rights reserved.