Highly fluorescent nitrogen and boron doped carbon quantum dots for selective and sensitive detection of Fe3+
Highly fluorescent nitrogen and boron doped carbon quantum dots for selective and sensitive detection of Fe3+
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高荧光氮和硼掺杂碳量子点，用于选择性和灵敏地检测 Fe3
DOI：
10.1039/d1tb00371b
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发表时间：
2021
影响因子：
7
通讯作者：
Li Run
中科院分区：
文献类型：
--
作者：
Zhang Yunhao;Qin Hongxin;Huang Yuting;Zhang Feng;Liu Hairong;Liu Hongbo;Wang Zi Jun;Li Run
由于Fe 3+在生理和病理过程中的重要作用，Fe 3+的检测在疾病诊断和环境保护领域受到越来越多的关注。然而，大多数现有的方法需要繁琐的样品预处理或复杂和昂贵的测试设备。最近，碳量子点已经发现了广泛的应用，例如用于Fe 3+测定的纳米探针，尽管具有有限的灵敏度和选择性。本文以柠檬酸、硼酸和乙二胺为前驱体，采用两步水热法合成了核壳结构的碳量子点B1 N2 CQDs。所得B1 N2 CQD具有优异的水溶性和显著的稳定性，以及高达15.4%的荧光量子产率。此外，B1 N2 CQD的荧光仅被Fe 3+猝灭，而其他金属离子的干扰最小。Fe 3+浓度在2-160 μM范围内与荧光猝灭量呈线性关系，相关系数R2 = 0.998，检测限为80 nM。最后，将B1 N2 CQDs作为一种高效的荧光探针应用于河水样品中Fe 3+的检测和生物体系中细胞内Fe 3+的成像。
Due to the essential role of Fe3+ in physiological and pathological processes, the detection of Fe3+ has drawn increasing attention in the field of disease diagnosis and environmental protection. However, most existing methods require either cumbersome sample pretreatment or sophisticated and expensive test equipment. Recently, carbon quantum dots have found a wide range of applications such as nanoprobes for Fe3+ determination, albeit with limited sensitivity and selectivity. Herein, we report core–shell carbon quantum dots B1N2CQDs via a two-step hydrothermal approach using citric acid, boric acid and ethylenediamine as precursors. The obtained B1N2CQDs exhibit excellent water solubility and remarkable stability as well as a high fluorescence quantum yield of 15.4%. In addition, the fluorescence of B1N2CQDs is quenched exclusively by Fe3+ with minimal interference from other metal ions. A linear relationship with R2 = 0.998 was observed between the fluorescence quenching capacity and the Fe3+ concentration in the range of 2–160 μM, with the limit of detection calculated to be 80 nM. Finally, the as-prepared B1N2CQDs were successfully applied as a highly efficient fluorescent probe for Fe3+ detection in river water samples and intracellular Fe3+ imaging in biological systems.