Epidemiologic study of hypothyroidism in Jiangsu province
Epidemiologic study of hypothyroidism in Jiangsu province
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发表时间：
2008-06
影响因子：
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通讯作者：
Y. Duan;Chao Liu;Shang-yong Feng;Xiao-dong Wang;Wei Tang;X. Mao;Shu-hang Xu;Yu Feng
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作者：
Y. Duan;Chao Liu;Shang-yong Feng;Xiao-dong Wang;Wei Tang;X. Mao;Shu-hang Xu;Yu Feng
目的了解江苏省社区人群甲状腺功能减退症（甲减）的患病情况及流行病学特征。方法采用分层整群抽样技术，抽取江苏省城乡六层居住满5年、20岁以上的居民。对7122例健康体检者进行血清sTSH测定，对sTSH异常者进行FT 3、FT 4测定。结果（1）总人群显性甲减和亚临床甲减的粗患病率分别为0.66%和7.53%，标化率分别为0.43%和6.28%。（2）女性甲减和亚临床甲减的患病率明显高于男性（均P <0.05）。(3)男女亚临床甲减患病率均随年龄增长而增高（P<0.05）。结论与甲减相比，江苏省亚临床甲减患病率较高，应重视亚临床甲减的随访和诊断。关键词：甲状腺功能减退;甲状腺功能减退，亚临床;流行病学调查
Objective To investigate the prevalence and epidemiologic characteristics of hypothyroidism among community population in Jiangsu province. Methods The residents who had lived for at least five years and aged more than 20 years old were sampled from six layers in urban and rural districts of Jiangsu province by a stratified cluster sampling technique. Serum was sampled from 7 122 subjects and sTSH was measured by chemiluminescence immunoassay, and FT3 and FT4 were determined in the subjects with abnormal sTSH level. Results (1) The crude prevalences of overt hypothyroidism and subclinical hypothyroidism were 0.66% and 7.53% respectively in total population, with the respective standardized rates of 0.43% and 6.28%. (2)The prevalences of hypothyroidism and subclinical hypothyroidism were significantly higher in females than in males (both P <0.05). (3) The prevalence of subclinical hypothyroidism was significantly increased with advancing age in both female and males (P<0.05). Conclusion Comparing with hypothyroidism, subclinical hypothyroidism shows higher prevalence in Jiangsu province, and more attention should be paid to the follow-up and diagnosis of subclinical hypothyroidism. Key words: Hypothyroidism; Hypothyroidism, subclinical; Epidemiologic survey