Prevention of Coronary Atherosclerosis by Estrogen‐Androgen Administration in the Cholesterol‐Fed Chick
Prevention of Coronary Atherosclerosis by Estrogen‐Androgen Administration in the Cholesterol‐Fed Chick
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通过给予胆固醇喂养的雏鸡雌激素-雄激素来预防冠状动脉粥样硬化
DOI：
10.1161/01.res.1.1.94
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发表时间：
1953
影响因子：
20.1
通讯作者：
L. Katz
中科院分区：
文献类型：
--
作者：
J. Stamler;R. Pick;L. Katz
雌激素在预防和治疗胆固醇诱导的公鸡冠状动脉粥样硬化方面都非常有效。绝经前妇女对冠状动脉硬化的相对免疫力可能与这些卵巢激素的存在有关。因此，雌激素可能是有用的治疗人类冠状动脉粥样硬化。考虑到这一目标，消除雌激素的女性化效应将是非常可取的。本实验证明，雄激素和雌激素的共存可维持公鸡的雄性特征，而不影响雌激素对冠状动脉的有益作用。
Estrogens are highly effective both prophylactically and therapeutically against cholesterol-induced coronary atherogenesis in cockerels. The relative immunity of premenopausal women to coronary sclerosis may be related to the presence of these ovarian hormones. Therefore, estrogens may be useful in the treatment of human coronary atherosclerosis. With this object in mind, the elimination of the feminizing effects of estrogens would be highly desirable. The present experiments prove that concomitant exhibition of androgens and estrogens maintain masculine sex characteristics without interfering with the beneficent effect of estrogens on the coronary arteries in cockerels.