Microfluidics: A new tool for modeling cancer-immune interactions.
Microfluidics: A new tool for modeling cancer-immune interactions.
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DOI：
10.1016/j.trecan.2015.12.003
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发表时间：
2016-01-01
期刊：
影响因子：
18.4
通讯作者：
Kamm RD
中科院分区：
文献类型：
--
作者：
Boussommier-Calleja A;Li R;Chen MB;Wong SC;Kamm RD
认识到免疫疗法对抗癌症的巨大潜力，对肿瘤和免疫细胞之间相互作用的研究已经加速，导致 FDA 最近批准了几种减少癌症进展的药物。免疫细胞可以通过多种细胞和分子相互作用来干预转移级联反应，从而开发了几种可以重现这些过程的体内和体外模型系统。其中，微流控技术具有许多优势，因为其独特的能力能够捕捉三维多细胞类型相互作用的基本特征，同时允许严格控制微环境和实时监测。在这里，我们回顾当前的检测方法并讨论用于免疫治疗的新微流体技术的开发。
In recognition of the enormous potential of immunotherapies against cancer, research into the interactions between tumor and immune cells has accelerated, leading to the recent FDA approval of several drugs that reduce cancer progression. Numerous cellular and molecular interactions have been identified by which immune cells can intervene in the metastatic cascade, leading to the development of several in vivo and in vitro model systems that can recapitulate these processes. Among these, microfluidic technologies hold many advantages in terms of their unique ability to capture the essential features of multiple cell type interactions in three-dimensions while allowing tight control of the microenvironment and real-time monitoring. Here, we review current assays and discuss the development of new microfluidic technologies for immunotherapy.