Automated neuropsychological assessment metrics (ANAM) measures of cognitive effects of Alzheimer's disease
Automated neuropsychological assessment metrics (ANAM) measures of cognitive effects of Alzheimer's disease
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DOI：
10.1016/j.acn.2004.09.001
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发表时间：
2005-05-01
影响因子：
2.6
通讯作者：
Harrison, M
中科院分区：
文献类型：
--
作者：
Levinson, D;Reeves, D;Harrison, M
八名阿尔茨海默病患者和八名年龄匹配的对照组接受了MMSE，Yesavage GDS和自动神经心理评估（ANAM）电池的定制子集。准确性（百分比正确）和效率（每分钟的正确反应数）的性能六ANAM任务进行了评估。患者的GDS评分显示无抑郁。虽然他们的MMSE评分（平均值接近25）明显低于对照组，但他们仍然表明患者的功能仍然处于相当高的水平。ANAM准确性评分的分析表明，患者在测量工作记忆的三项任务中明显受损。判别函数分析表明，93.8%的正确分类。ANAM效率评分分析显示，除了简单的反应时间，患者在所有的任务显着受损。判别函数分析正确分类100%的参与者。鉴于本研究中的组规模较小，这一发现特别强调了ANAM对阿尔茨海默病认知影响的敏感性，正如大效应量所示。研究结果进一步表明，ANAM可能能够在疾病进展的早期阶段检测到疾病的更微妙的影响。(c)2004年美国国家神经心理学学会。由爱思唯尔有限公司出版。保留所有权利。
Eight individuals with Alzheimer's disease, and eight age-matched controls, were administered the MMSE, the Yesavage GDS, and a customized subset of the Automated Neuropsychological Assessment Metrics (ANAM) Battery. Accuracy (percent correct) and efficiency (number of correct responses per minute) of performance on six ANAM tasks were assessed. The patients' GDS scores indicated no depression. Although their MMSE scores (mean similar to 25) were significantly lower than those of the controls, they nonetheless indicated that the patients were still functioning at a fairly high level. Analysis of ANAM accuracy scores indicated that the patients were significantly impaired on three tasks measuring working memory. A discriminant function analysis revealed 93.8% correct classification. Analysis of ANAM efficiency scores revealed that except for simple reaction time, the patients were significantly impaired on all tasks. A discriminant function analysis correctly classified 100% of the participants. Given the small size of the groups in the present study, this finding especially underscores the sensitivity of ANAM to the cognitive effects of Alzheimer's disease, as indicated by the large effect sizes. The findings further indicate that ANAM might be capable of detecting more subtle effects of the disease at an earlier stage in its progress. (c) 2004 National Academy of Neuropsychology. Published by Elsevier Ltd. All rights reserved.