Telomeres, the nucleolus and aging
Telomeres, the nucleolus and aging
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DOI：
10.1016/s0955-0674(98)80008-2
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发表时间：
1998-06-01
影响因子：
7.5
通讯作者：
Guarente, L
中科院分区：
文献类型：
--
作者：
Johnson, FB;Marciniak, RA;Guarente, L
培养的人类细胞中端粒酶的重新激活将其复制寿命延长到超出海弗利克极限。端粒缩短如何引发细胞衰老以及它是否会导致体内衰老正在研究中。对酵母的研究揭示了另一个对细胞衰老至关重要的部位：核仁。核糖体 DNA 环的积累是该生物体衰老的原因。这种机制与人类衰老的可能相关性也在考虑之中。
Reactivation of telomerase in cultured human cells extends their replicative life span beyond the Hayflick limit. How telomere shortening triggers cell senescence and whether it contributes to aging in vivo are under investigation. Studies in yeast have revealed another site critical to cellular aging: the nucleolus. The accumulation of ribosomal DNA circles is a cause of aging in this organism. The possible relevance of this mechanism to human aging is also being considered.