Novel-object place conditioning in adolescent and adult male and female rats: effects of social isolation
Novel-object place conditioning in adolescent and adult male and female rats: effects of social isolation
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DOI：
10.1016/j.physbeh.2003.08.003
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发表时间：
2003-11-01
影响因子：
2.9
通讯作者：
Spear, LP
中科院分区：
文献类型：
--
作者：
Douglas, LA;Varlinskaya, EI;Spear, LP
寻求新鲜感的程度在青春期经常出现。最近使用条件性位置偏爱(CPP)范式的研究表明，对成年大鼠来说，新奇可能是有益的。本研究通过对群居和隔离饲养的青春期和成年雄性和雌性SD大鼠的CPP进行评估，探讨了年龄、性别和隔离压力对新奇寻求和新奇奖励的影响。在条件反射过程中，青春期动物对新事物的反应比成年动物更高，只有在成年后才会受到社会孤立的抑制，特别是在雄性动物中。新奇物体CPP在青春期男性中表现得很强，而只有与社会隔离的成年男性才表现出对与新奇物体配对的隔室的偏好。这种年龄差异在女性中并不明显，青春期和成年组的女性都是集体居住的女性，但不是孤立的女性，显示出新奇物体的位置制约。在CPP范式中，条件化过程中的新奇引导行为和新奇奖励之间的这种分离支持了这样一种观点，即新奇寻求的潜在机制与参与新奇奖励效应的机制是可以分离的。青少年表现出的高水平的新奇追求并不一定预示着新奇的高回报特性，后者也受到环境和性别相关因素的影响。(C)2003 Elsevier Inc.保留所有权利。
Elevated levels of novelty seeking are often seen during adolescence. Recent studies using a conditioned place preference (CPP) paradigm have shown that novelty may be rewarding for adult rats. The present study explored the impact of age, sex, and isolation stress on novelty seeking and novelty reward by assessing novel object-induced CPP in adolescent and adult male and female Sprague-Dawley rats housed either socially or in isolation. Responding to the novel objects during conditioning was higher in adolescent animals than adults, and was suppressed by social isolation only in adulthood, particularly among males. Novel object CPP was strong among adolescent males, whereas only socially isolated adult males demonstrated preference for the compartment paired with the novel objects. This age difference was not evident in females, with both adolescent and adult group-housed females, but not their isolated counterparts, showing novel-object place conditioning. These dissociations between novelty-directed behaviors during conditioning and novelty reward in the CPP paradigm support the suggestion that mechanisms underlying novelty seeking are separable from those involved in the rewarding effects of novelty. High levels of novelty seeking demonstrated by adolescents do not necessarily predict high rewarding properties of novelty, with the latter also being influenced by environmental and gender-related factors. (C) 2003 Elsevier Inc. All rights reserved.