Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study
Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study
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DOI：
10.1016/j.envint.2019.105139
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发表时间：
2019-12-01
影响因子：
11.8
通讯作者：
Kishi, Reiko
中科院分区：
文献类型：
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作者：
Itoh, Sachiko;Araki, Atsuko;Kishi, Reiko
背景：甲状腺抗体（TA）是妊娠期间甲状腺功能减退症的最常见原因。尽管之前的研究发现，产前接触全氟烷基物质 (PFAS) 会扰乱人类的甲状腺激素 (TH)，但其对围产期 TA 的影响尚未得到研究。目的：探讨产前接触来自两个不同组的 11 种不同 PFAS（羧酸盐和磺酸盐）与母体和脐带血中 TH 和 TA 表达之间的关联，同时考虑母体 TA 状态。方法：在前瞻性出生队列（北海道研究）中，我们纳入了 2002 年至 2005 年招募的 701 对母婴，这些母体和脐带血样本均可用。使用超高效液相色谱结合三重四极杆串联质谱法测量了妊娠 28-32 周时获得的母体血浆中的 11 种 PFAS。检测妊娠早期（中位妊娠 11 周）母血和出生时脐带血中的 TH 和 TA，包括促甲状腺激素 (TSH)、游离三碘甲状腺原氨酸 (FT3)、游离甲状腺素 (FT4)、甲状腺过氧化物酶抗体 (TPOAb) 和甲状腺球蛋白抗体 (TgAb)。 结果：母体血清中 TgAb 和 TPOAb 的中位水平为 15.0和 6.0 IU/mL。新生儿的中位 TgAb 水平为 38.0 IU/mL，仅在 12.3% 的样本中检测到 TPOAb。在 TA 阳性和 TA 阴性母亲中，母亲 FT3 水平与 PFAS 水平呈正相关。母体全氟辛酸与母体 TPOAb 呈负相关。在男孩中，一些母亲 PFAS 与母亲 TA 阴性组中较高的 TSH 和较低 FT3 水平相关，而全氟癸酸与母亲 TA 阳性组中较低的 TSH 水平相关。在女孩中，母亲的某些 PFAS 与 TA 阴性母亲组中较低的 TSH 和较高 FT3 相关，而全氟十二烷酸与 TA 阳性母亲中较低的 FT4 相关。在母亲 TA 阴性组中，母亲 PFAS 与男孩 TgAb 呈负相关，在母亲 TA 阳性组中，母亲 PFAS 与女孩 TgAb 呈正相关。结论：我们的结果表明，PFAS 暴露和易感性对甲状腺的干扰作用因母亲 TA 水平而异。
Background: Thyroid antibodies (TAs) are the most common cause of hypothyroidism during gestation. Although previous studies found that prenatal exposure to perfluoroalkyl substances (PFASs) disrupts thyroid hormones (THs) in humans, their effects on TAs during the perinatal period have not been investigated. Objective: To explore the associations between prenatal exposure to eleven different PFASs from two different groups (carboxylates and sulfonates) and the expression of THs and TAs in maternal and cord blood while considering maternal TA status.Methods: In a prospective birth cohort (the Hokkaido Study), we included 701 mother-neonate pairs recruited in 2002-2005 for whom both prenatal maternal and cord blood samples were available. Eleven PFASs were measured in maternal plasma obtained at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. THs and TAs including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured in maternal blood during early pregnancy (median 11 gestational weeks), and in cord blood at birth.Results: The median levels of TgAb and TPOAb in maternal serum were 15.0 and 6.0 IU/mL, respectively. The median TgAb level in neonates was 38.0 IU/mL, and TPOAb were detected in only 12.3% of samples. Maternal FT3 level was positively associated with PFAS levels in both TA-positive and TA-negative mothers. Maternal perfluorooctanoate was inversely associated with maternal TPOAb. Among boys, some maternal PFASs were associated with higher TSH and lower FT3 levels in maternal TA-negative group, while perfluorodecanoic acid was associated with lower TSH in maternal TA-positive group. Among girls, some PFAS of mothers showed associations with lower TSH and higher FT3 in maternal TA-negative group, while perfluorododecanoic acid was associated with lower FT4 in maternal TA-positive. Maternal PFASs showed associations with boy's TgAb inversely in maternal TA-negative group and with girl's TgAb positively in maternal TA-positive group.Conclusions: Our results suggest thyroid disrupting effects of PFAS exposure and susceptibility vary depending on maternal TA levels.