DNA interaction of new copper(II) complexes with sulfonamides as ligands
DNA interaction of new copper(II) complexes with sulfonamides as ligands
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DOI：
10.1016/j.jinorgbio.2006.11.007
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发表时间：
2007-03-01
影响因子：
3.9
通讯作者：
Castineiras, Alfonso
中科院分区：
文献类型：
--
作者：
Macias, Benigno;Villa, Maria V.;Castineiras, Alfonso
合成并表征了一种新型的磺胺类铜（H）配合物。磺酰胺配体通过8-氨基喹啉与2-均三甲苯（Hqmesa）、4-叔丁基苯（Hqtbsa）或α-甲苯（H α qtsa）磺酰氯之间的反应制备。对配合物[Cu（alpha qtsa）（2）]进行的结构分析表明，Cu（II）阳离子的局部环境介于正方形平面和四面体几何形状之间，相邻分子之间的磺酰基配体的苯环堆叠。室温下的粉末EPR谱给出了[Cu（alpha qtsa）（2）]和[Cu（qmesa）（2）]配合物的菱形谱，以及[Cu（qtbsa）（2）]配合物的轴向谱，这可能是由于甲基的空间位阻。配合物[Cu（alpha qtsa）（2）]和[Cu（qmesa）（2）]是在抗坏血酸钠存在下降解DNA的人工化学核酸酶。对自由基清除剂的研究表明，参与DNA损伤的ROS（活性氧）是羟基、类单线态氧和超氧阴离子。(c)2006爱思唯尔公司All rights reserved.
New copper(H) complexes with sulfonamide ligands have been prepared and characterized. Sulfonamide ligands were prepared through a reaction between 8-aminoquinoline and either 2-mesitylene (Hqmesa), 4-tert-butylbenzene (Hqtbsa), or alpha-toluene (H alpha qtsa) sulfonyl chlorides. The structural analysis carried out for complex [Cu(alpha qtsa)(2)] indicated that the local environment of the Cu(II) cation is between a square planar and a tetrahedral geometry, with stacking of the benzene rings of the sulfonyl ligands between neighbor molecules. Powder EPR spectra at room temperature gave rhombic spectra for the [Cu(alpha qtsa)(2)] and [Cu(qmesa)(2)] complexes and an axial spectrum for the [Cu(qtbsa)(2)] complex, probably due to the steric hindrance of the methyl groups. Complexes [Cu(alpha qtsa)(2)] and [Cu(qmesa)(2)] are artificial chemical nucleases that degrade DNA in the presence of sodium ascorbate. A study of the radical scavengers revealed that the ROS (reactive oxygen species) involved in the DNA damage were hydroxyl, singlet oxygen-like species, and superoxide anion. (c) 2006 Elsevier Inc. All rights reserved.