Structure and lipophilicity--the keys to understanding the function of pyruvate derivatives for ischemia/reperfusion?
Structure and lipophilicity--the keys to understanding the function of pyruvate derivatives for ischemia/reperfusion?
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结构和亲脂性——理解丙酮酸衍生物缺血/再灌注功能的关键？
DOI：
10.1016/j.jss.2009.12.007
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Abarbanell,AaronM
中科院分区：
文献类型：
--
作者：
Abarbanell,AaronM
丙酮酸盐和丙酮酸盐衍生物是基础科学研究的一大焦点，因为它们能够减少炎症和响应于损伤的器官功能障碍。在动物模型中，已知丙酮酸钠（NaPyr）或阴离子形式的丙酮酸盐可减轻损伤后的心肌、肾脏和肝脏器官功能障碍[1-3]。丙酮酸盐也与严重休克后的结局改善相关[4，5]。然而，NaPyr在水溶液中不稳定，并且经历可能限制其有效性的水合和缩合反应[6]。为了解决这个问题，Fink博士的小组研究了丙酮酸乙酯（EP）（丙酮酸衍生物）的作用，并报告在肠缺血/再灌注（I/R）模型中EP的作用上级丙酮酸[7]。该小组随后报告了EP在脓毒症和炎症模型中的保护作用[8-10]。现在在Cruz及其同事的这份手稿中，该小组研究了可能区分EP和其他丙酮酸衍生物与丙酮酸的保护作用的潜在机制。
Pyruvate and pyruvate derivatives are a large focus of basic science research due to their ability to decrease inflammation and organ dysfunction in response to injury. In animal models sodium pyruvate (NaPyr) or the anion form pyruvate are known to attenuate myocardial, renal and hepatic organ dysfunction after injury [1–3]. Pyruvate is also associated with improved outcomes after severe shock [4, 5]. However, NaPyr is not stable in aqueous solutions and undergoes hydration and condensation reactions that may limit its effectiveness [6].In an attempt to solve this problem, Dr. Fink’s group studied the effects of ethyl pryuvate (EP), a pyruvate derivative, and reported that the effects of EP were superior to pyruvate in a model of intestinal ischemia/reperfusion (I/R)[7]. This group subsequently reported the protective role of EP in models of sepsis and inflammation [8–10]. Now in this manuscript by Cruz and colleagues, the group investigated the underlying mechanisms that might differentiate the protective role of EP and other pyruvate derivatives from pyruvate.