Serum CD109 levels reflect the node metastasis status in head and neck squamous cell carcinoma.
Serum CD109 levels reflect the node metastasis status in head and neck squamous cell carcinoma.
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DOI：
10.1002/cam4.3737
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发表时间：
2021-03
期刊：
影响因子：
4
通讯作者：
Hanai N
中科院分区：
文献类型：
--
作者：
Hagiwara S;Sasaki E;Hasegawa Y;Suzuki H;Nishikawa D;Beppu S;Terada H;Sawabe M;Takahashi M;Hanai N
人们正在开发各种生物标志物，用于癌症的早期诊断和预测其预后。本研究旨在评价血清CD109在头颈部鳞状细胞癌(HNSCC)诊断中的意义。采用酶联免疫吸附试验(EL ISA)对56例HNSCC患者手术前后共112例血清CD109水平进行了检测。评估与术前血清CD109水平和CD109指数(定义为术前血清CD109水平与术后血清CD109水平的比率)均有统计学意义的临床因素。并分析血清CD109水平与淋巴结密度(LND)、淋巴侵袭等病理特征及血清SCC抗原水平的相关性。ELISA法检测结果显示，淋巴结转移阳性和IV期患者术前血清CD109水平分别高于I+II+III期患者和无转移患者。多因素回归分析显示，血清CD109水平与淋巴结转移状态显著相关。Spearman等级相关分析也显示，术前血清CD109水平与LND呈正相关。此外，术前血清CD109水平为≥38.0 ng/ml、CD109指数为≥1.6的患者的总生存率和无复发生存概率显著低于其他患者。血清CD109水平与鳞癌抗原水平无明显相关性。晚期患者血清CD109水平升高，反映了肿瘤的转移情况。血清CD109可作为判断HNSCC淋巴结转移的新指标。应用酶联免疫吸附试验对56例头颈部鳞状细胞癌患者手术前后共112份血清标本的CD109水平进行了分析。晚期肿瘤患者血清CD109水平明显升高，且血清CD109水平高的患者总体无复发生存概率明显降低。血清CD109可作为判断头颈部鳞状细胞癌淋巴转移的新的预后指标。
Various biomarkers are being developed for the early diagnosis of cancer and for predicting its prognosis. The aim of this study is to evaluate the diagnostic significance of serum CD109 in head and neck squamous cell carcinoma (HNSCC). The serum CD109 levels in a total of 112 serum samples collected before and after surgery from 56 HNSCC patients were analyzed with an enzyme‐linked immunosorbent assay (ELISA). The clinical factor that showed a statistically significant association with both the preoperative serum CD109 level, and the CD109 index: which was defined as the ratio of the preoperative serum CD109 level to the postoperative serum CD109 level, were assessed. The correlations between the serum CD109 levels and lymph node density (LND), pathological features such as lymphatic invasion, and serum SCC antigen levels were also assessed. The ELISA measurement revealed that preoperative serum CD109 levels were elevated in patients with node metastasis‐positive and stage IV disease, in comparison to those with node metastasis‐negative and Stage I+II+III disease, respectively. A multiple regression analysis indicated that serum CD109 level was significantly associated with the node metastasis status. A Spearman's rank correlation analysis also revealed a positive correlation between the preoperative serum CD109 level and LND. Furthermore, the probabilities of the overall and relapse‐free survival were significantly lower in patients with a preoperative serum CD109 level of ≥38.0 ng/ml and a CD109 index of ≥1.6, respectively, than in others. There was no significant correlation between the serum CD109 and SCC antigen levels. The serum CD109 levels were elevated in patients with advanced stage disease, reflecting the node metastasis status. CD109 in sera could be a novel prognostic marker for HNSCC involving lymph node metastasis. The serum CD109 levels in a total of 112 serum samples collected before and after surgery from 56 head and neck squamous cell carcinoma patients were analyzed with an enzyme‐linked immunosorbent assay. The serum CD109 levels were elevated in patients with advanced stage disease due to the node metastasis status, and the probability of overall and relapse‐free survival was significantly lower in patients with a high levels of serum CD109. CD109 in sera could be a novel prognostic marker for head and neck squamous cell carcinoma involving lymph node metastasis.
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