Parental smoking and lung function: Misclassification due to background exposure to passive smoking
Parental smoking and lung function: Misclassification due to background exposure to passive smoking
复制标题
DOI：
10.1016/j.rmed.2006.08.004
复制
发表时间：
2007-04-01
影响因子：
4.3
通讯作者：
Forastiere, Francesco
中科院分区：
文献类型：
--
作者：
Corbo, Giuseppe M.;Agabiti, Nera;Forastiere, Francesco
在评估父母吸烟对青少年肺功能的影响时，我们评估了背景暴露（即暴露于环境烟草烟雾，ETS，来自父母吸烟以外的来源）所起的作用。我们进行了横断面调查（937青少年）在拉齐奥大区。通过问卷调查收集数据，测量肺功能和尿可替宁与肌酐比值（CCR）。我们发现，62.1%的受试者暴露于目前的父母吸烟。在355名未暴露于父母吸烟的青少年中，共有92名（25.9%）的CCR水平大于分布的中位数（17.3 ng/mg）。父母吸烟的受试者的FVC高于父母不吸烟的受试者，FEV/ FVC比值显著低于父母不吸烟的受试者。当通过单独研究那些没有父母暴露但CCR > 17.3的人来从未暴露组中去除“背景”ETS暴露时，结果显示由于父母吸烟而导致的肺功能降低比先前的模型更大。我们的研究进一步证明了ETS对青少年肺功能的有害影响。如果在分析中未考虑背景暴露，则应重新审查父母吸烟对肺功能影响的阴性结果。(c)2006爱思唯尔有限公司版权所有。
We evaluated the role played by background exposure (i.e. exposure to Environmental Tobacco Smoke, ETS, from sources other than parental smoking) when evaluating the effect of parental smoking on lung function of adolescents. We performed a cross-sectional survey (937 adolescents) in the Lazio Region. Data were collected by a questionnaire, lung function tests and urinary cotinine to creatinine ratios (CCR) were measured. We found that 62.1% of subjects were exposed to current parental smoke. Among the 355 adolescents not exposed to parental smoke, a total of 92 (25.9%) had CCR levels greater than the median value of the distribution (17.3 ng/mg). Subjects with smoking parents had higher FVC and significant tower FEV, / FVC ratios than subjects without smoking parents. When "Background" ETS exposure was removed from the unexposed group by separately studying those without parental exposure but with CCR > 17.3, results showed a reduction in lung function due to parental smoking which is greater compared to the previous model. Our study adds further evidence regarding the detrimental effect of ETS on Lung function of adolescents. Negative results on the effect of parental smoking on lung function should be revisited if background exposure has not been considered in the analysis. (c) 2006 Elsevier Ltd. All rights reserved.