CINV: still troubling patients after all these years.
CINV: still troubling patients after all these years.
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DOI：
10.1007/s00520-018-4131-3
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Aapro M
中科院分区：
文献类型：
--
作者：
Aapro M
化疗引起的恶心和呕吐（CINV）是癌症患者最担心的副作用之一。导致急性和迟发性 CINV 的精确生理机制不断被阐明，并为开发针对这些途径的止吐疗法提供了机会。针对血清素和神经激肽-1 的受体拮抗剂的出现彻底改变了 CINV 的预防，显着减少了这种副作用的影响并改善了患者的生活质量。然而，仍有几个领域的需求未得到满足，包括在接受癌症化疗的患者中充分预防恶心，而不仅仅是呕吐。延迟性 CINV 和预期性 CINV 的预防以及突破性 CINV 的管理也继续给患者和临床医生带来挑战。正在进行的研究继续针对这些领域，以改进止吐疗法和指南。
Chemotherapy-induced nausea and vomiting (CINV) is one of the most feared side effects experienced by patients with cancer. The precise physiologic mechanisms responsible for acute and delayed CINV continue to be elucidated and have provided an opportunity to develop antiemetic therapies targeting these pathways. The emergence of receptor antagonists targeting serotonin and neurokinin-1 have revolutionized the prevention of CINV, significantly reducing the impact of this side effect and improving patient quality of life. However, several areas of unmet need remain, including adequate prevention of nausea, rather than just vomiting, in patients receiving chemotherapy for cancer. Prevention of delayed CINV and anticipatory CINV, as well as management of breakthrough CINV, also continues to challenge patients and clinicians. Ongoing research continues to address these areas to improve antiemetic therapies and guidelines.
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