Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the TL10 promoter-592 C/C genotype
Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the TL10 promoter-592 C/C genotype
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DOI：
10.1016/s1521-6616(03)00214-6
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发表时间：
2003-11-01
影响因子：
8.6
通讯作者：
Martínez-Maza, O
中科院分区：
文献类型：
--
作者：
Breen, EC;Boscardin, WJ;Martínez-Maza, O
白细胞介素-10（IL-10）可能有助于非霍奇金B细胞淋巴瘤的发展，特别是在获得性免疫缺陷综合征（AIDS）的背景下，淋巴瘤的发病率大大增加。利用多中心艾滋病队列研究（MACS）在诊断艾滋病相关淋巴瘤之前获得的标本，在淋巴瘤病例中更常见可检测的血清人IL 10（n = 61，26%）与CD 4匹配的AIDS对照组（5%，P = 0.004）、HIV感染者（2%，P = 0.002）或HIV未感染者（0%，P = 0.0003）相比。在纵向研究中，可检测到的IL 10发生在最接近但在淋巴瘤诊断之前的时间（P = 0.01）。在对1157名MACS受试者的IL 10基因启动子区域内的单核苷酸多态性进行的独立遗传分析中，高IL 10表达基因型（-592 C/C）在淋巴瘤受试者中的代表性过高（P = 0.009），即使控制了种族（P = 0.006）。这些结果表明，血清IL 10或IL 10启动子-592 C/C基因型升高与AIDS淋巴瘤的发展有关。(C)2003年爱思唯尔公司All rights reserved.
Interleukin-10 (IL10) may contribute to the development of non-Hodgkin's B cell lymphoma, especially in the context of acquired immunodeficiency syndrome (AIDS), where lymphoma incidence is greatly increased. Utilizing specimens from the Multicenter AIDS Cohort Study (MACS) obtained prior to diagnosis of AIDS-associated lymphoma, detectable serum human IL10 was seen much more frequently in lymphoma cases (n = 61, 26%) compared to CD4-matched AIDS controls (5%, P = 0.004), or to HIV-infected (2%, P = 0.002) or HIV uninfected subjects (0%, P = 0.0003). In longitudinal studies, detectable IL10 occurred at times closest to but preceding lymphoma diagnosis (P = 0.01). In an independent genetic analysis of single-nucleotide polymorphisms within the promoter region of the IL10 gene in 1157 MACS subjects, a high IL10-expressing genotype (-592 C/C) was overrepresented among lymphoma subjects (P = 0.009), even when controlling for race (P = 0.006). These results suggest that elevated serum IL10 or the IL10 promoter -592 C/C genotype are associated with development of AIDS lymphoma. (C) 2003 Elsevier Inc. All rights reserved.