An estimate of phthalate exposure among pregnant women living in Trujillo, Peru
An estimate of phthalate exposure among pregnant women living in Trujillo, Peru
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DOI：
10.1016/j.chemosphere.2010.06.048
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发表时间：
2010-09-01
期刊：
影响因子：
8.8
通讯作者：
Naeher, Luke P.
中科院分区：
文献类型：
--
作者：
Irvin, Elizabeth Ann;Calafat, Antonia M.;Naeher, Luke P.
邻苯二甲酸酯是一组用作增塑剂和添加剂的邻苯二甲酸酯。在实验室动物中，几种邻苯二甲酸酯是已知的内分泌干扰物。一些研究描述了美国和发达国家的邻苯二甲酸酯暴露，但对发展中国家的邻苯二甲酸酯暴露知之甚少，特别是在怀孕期间。为了评估六种不同邻苯二甲酸酯的暴露，我们测量了居住在秘鲁特鲁希略的72名妇女在妊娠早期、中期和晚期采集的现场尿样中九种邻苯二甲酸酯代谢物的浓度。此外，妇女还填写了问卷，以提供人口统计特征。通过线性模型进行统计分析，以评估邻苯二甲酸酯代谢物浓度的潜在差异，按三个月，烹饪燃料类型，社会经济地位和教育。在>40%的分析样品中检测到所有代谢物，在>90%的样品中发现邻苯二甲酸单正丁酯、邻苯二甲酸单（2-乙基-5-羧基戊基）酯和邻苯二甲酸单乙酯。与美国一般人群中的孕妇相比，这组生活在秘鲁的孕妇的9种未校正的尿液代谢物中有5种和9种肌酐校正的尿液代谢物中有4种显著较低。(C)2010爱思唯尔有限公司版权所有。
Phthalates are a group of phthalic acid esters which are used as plasticizers and additives. In laboratory animals, several phthalates are known endocrine disruptors. Several studies have described phthalate exposure in the United States and developed countries but little is known about phthalate exposure in the developing world, particularly during pregnancy. To assess exposure to six different phthalates, we measured the concentrations of nine phthalate metabolites in spot urine samples collected during the first, second, and third trimester of pregnancy from a group of 72 women living in Trujillo, Peru. Additionally, women completed questionnaires to provide demographic characteristics. Statistical analysis via linear models was used to evaluate potential differences in the concentrations of phthalate metabolites by trimester, cooking fuel type, socioeconomic status, and education. All metabolites were detected in >40% of samples analyzed, and mono-n-butyl phthalate, mono (2-ethyl-5-carboxypentyl) phthalate, and monoethyl phthalate were found in >90% of samples. Five of nine unadjusted urinary metabolites and four of nine creatinine-adjusted urinary metabolites were significantly lower in this group of pregnant women living in Peru compared to pregnant women in the US general population. (C) 2010 Elsevier Ltd. All rights reserved.