COMPARISON OF ARTERIAL-WALL MECHANICS IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS
COMPARISON OF ARTERIAL-WALL MECHANICS IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS
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DOI：
10.1152/ajpheart.1979.237.2.h159
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发表时间：
1979-01-01
影响因子：
--
通讯作者：
COX, RH
中科院分区：
文献类型：
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作者：
COX, RH
采用Wistar （NW）、Kyoto Wistar （WKY）和自发性高血压大鼠（SHR）的颈动脉段比较力学性能和结缔组织组成。在主动（5 .mu）条件下进行了压力-直径测量。g/ml去甲肾上腺素)和被动(0 mM Ca2+和2 mM EGTA[乙二醇-二苯二甲酸乙酯]。-氨基乙醚)N，N,N ",N " -四乙酸])平滑肌。收缩压平均为NW， 121±。3;嗯，124。4;SHR为187 +-。被动力学在SHR动脉中最硬，在NW动脉中最柔顺。胶原-弹性蛋白比值无显著差异，但SHR组胶原+弹性蛋白比值最低，NW组最高。这些结果与目前关于结缔组织元素对被动力学的贡献的概念不一致。最大应力发展方向为NW， 561 .+-。49个;Wky, 735。50;SHR为944 +-。79同学们。103达因/厘米2。在100毫米汞柱下，直径减小到NE的方向为NW， 17.6±。2.4%;哇，16.7 +-。2.0%;SHR为24.8 +-。2.4%。前者表明SHR中不同的收缩蛋白含量或更有效的细胞间力偶联。后者表明，由于更硬的被动肌肉元件和/或相对更大的壁厚，收缩装置更有效。
Segments of carotid artery from Wistar (NW), Kyoto Wistar (WKY) and spontaneously hypertensive rats (SHR) were used to compare mechanical properties and connective tissue composition. Pressure-diameter measurements were made under conditions of active (5 .mu.g/ml norepinephrine) and passive (0 mM Ca2+ and 2 mM EGTA [ethylene glycol-bis(.beta.-aminoethyl ether)N,N,N'',N''-tetraacetic acid]) smooth muscle. Systolic blood pressures averaged NW, 121 .+-. 3; WKY, 124 .+-. 4; and SHR, 187 .+-. 5 mm Hg. Passive mechanics were stiffest in SHR and most compliant in NW arteries. No differences in collagen-elastin ratio were found but collagen + elastin was lowest in SHR and highest in NW carotids. These results are not consistent with current concepts of the contribution of connective tissue elements to passive mechanics. Maximum stress development was NW, 561 .+-. 49; WKY, 735 .+-. 50; and SHR, 944 .+-. 79 .times. 103 dyn/cm2. Diameter reductions to NE at 100 mm Hg were NW, 17.6 .+-. 2.4%; WKY, 16.7 .+-. 2.0%; and SHR, 24.8 .+-. 2.4%. The former suggests different contractile protein contents or more efficient intercellular force coupling in SHR. The latter suggests a more effective contractile apparatus as a result of stiffer passive muscle elements and/or a relatively larger wall thickness.