EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat.
EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat.
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DOI：
10.1016/0925-4439(93)90111-d
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发表时间：
1993-04
期刊：
影响因子：
--
通讯作者：
Shinya Sato;T. Tominaga;T. Ohnishi;S. Ohnishi
中科院分区：
文献类型：
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作者：
Shinya Sato;T. Tominaga;T. Ohnishi;S. Ohnishi
用电子顺磁共振波谱技术研究了大鼠不同程度脑缺血时一氧化氮(NO)自由基的形成。采用二乙基二硫代氨基甲酸酯和柠檬酸铁作为体内自旋捕捉剂。NO自旋加合物信号随脑缺血程度的加重而增强。NG-硝基L-精氨酸甲酯可抑制NO自由基的生成。
The formation of nitric oxide (NO) radicals was demonstrated by electron paramagnetic resonance spectroscopy in the rat during varying degrees of brain ischemia. Diethyldithiocarbamate and Fe-citrate were used as in vivo spin-trapping reagents. The signal of NO spin adducts increased in accordance with the degree of ischemic insults. The formation of NO radicals was inhibited by NG-nitro]l-arginine methyl ester.