High prevalence of chronic kidney disease of unknown etiology among workers in the Mesoamerican Nephropathy Occupational Study.
High prevalence of chronic kidney disease of unknown etiology among workers in the Mesoamerican Nephropathy Occupational Study.
复制标题
DOI：
10.1186/s12882-022-02861-0
复制
发表时间：
2022-07-07
期刊：
影响因子：
2.3
通讯作者：
中科院分区：
文献类型：
--
作者：
病因不明的慢性肾脏病（CKDu）的死亡率在中美洲太平洋沿岸沿着非常高，特别是在甘蔗工人中。中美洲肾病职业研究（MANOS）是一项在萨尔瓦多和尼加拉瓜的农业和非农业工人中进行的CKDu前瞻性队列研究。本手稿的目的是描述两轮后MANOS队列招募、基线数据收集和CKDu患病率。从甘蔗、玉米、大蕉、制砖和道路建设行业招募了没有已知糖尿病、高血压或CKD的工人（n = 569）。调查人员发放问卷，收集生物样本，并在工地连续三个工作日观察工人。分析血清标本的肾功能参数，并用于计算估计的肾小球滤过率（eGFR）。在6个月时，在轮班前再次收集血清。基线CKD定义为两个时间点的eGFR ≤ 60 ml/min/1.73m2。根据行业、国家和人口统计学指标计算标准化患病率。根据CKD状态比较肾功能参数。基线时CKD患病率为7.4%（n = 42）。萨尔瓦多甘蔗业的标准化流行率最高（14.1%），其次是萨尔瓦多玉米业（11.6%）和萨尔瓦多制砖业（8.1%）。福建甘蔗的患病率最低，可能是由于就业前的肾功能筛查。尽管努力招募没有CKD的参与者，但我们在MANOS队列中农业和非农业工人中发现的CKD流行表明该地区的肾脏疾病值得注意，特别是在甘蔗工人中。
Mortality from chronic kidney disease of unknown etiology (CKDu) is extremely high along the Pacific coast of Central America, particularly among sugarcane workers. The Mesoamerican Nephropathy Occupational Study (MANOS) is a prospective cohort study of CKDu among agricultural and non-agricultural workers in El Salvador and Nicaragua. The objective of this manuscript is to describe the MANOS cohort recruitment, baseline data collection, and CKDu prevalence after two rounds. Workers with no known diabetes, hypertension, or CKD were recruited from sugarcane, corn, plantain, brickmaking, and road construction industries (n = 569). Investigators administered questionnaires, collected biological samples, and observed workers for three consecutive workdays at the worksite. Serum specimens were analyzed for kidney function parameters, and used to calculate estimated glomerular filtration rate (eGFR). At six months, serum was collected again prior to the work shift. CKD at baseline is defined as eGFR ≤ 60 ml/min/1.73m2 at both timepoints. Age-standardized prevalence was calculated by industry, country, and demographic measures. Kidney function parameters were compared by CKD status. Prevalence of CKD at baseline was 7.4% (n = 42). Age-standardized prevalence was highest in Salvadoran sugarcane (14.1%), followed by Salvadoran corn (11.6%), and Nicaraguan brickmaking (8.1%). Nicaraguan sugarcane had the lowest prevalence, likely due to kidney function screenings prior to employment. Despite efforts to enroll participants without CKD, our identification of prevalent CKD among agricultural and non-agricultural workers in the MANOS cohort indicates notable kidney disease in the region, particularly among sugarcane workers.
登录
查看更多内容
影响因子：
13.6
作者：
Gonzalez-Quiroz, Marvin;Smpokou, Evangelia-Theano;Caplin, Ben
通讯作者：
Caplin, Ben
影响因子：
6.3
作者：
Ordunez, Pedro;Nieto, F. Javier;Hoy, Wendy E.
通讯作者：
Hoy, Wendy E.
影响因子：
13.2
作者：
Gallo-Ruiz, Lyanne;Sennett, Caryn M.;Scammell, Madeleine K.
通讯作者：
Scammell, Madeleine K.
DOI：
10.1016/j.nefro.2016.03.018
发表时间：
2016-10-01
期刊：
Nefrología (Madrid)
影响因子：
--
作者：
García-Trabanino, Ramón;Hernández, Carolina;Domínguez Alonso, Jesús
通讯作者：
Domínguez Alonso, Jesús
DOI：
10.3390/ijerph18105418
发表时间：
2021-05-19
影响因子：
--
作者：
Petropoulos ZE;Ramirez-Rubio O;Scammell MK;Laws RL;Lopez-Pilarte D;Amador JJ;Ballester J;O'Callaghan-Gordo C;Brooks DR
通讯作者：
Brooks DR