Elevated levels of serum cholesterol are associated with better performance on tasks of episodic memory.
Elevated levels of serum cholesterol are associated with better performance on tasks of episodic memory.
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DOI：
10.1007/s11011-016-9797-y
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发表时间：
2016-04
影响因子：
3.6
通讯作者：
Milberg WP
中科院分区：
文献类型：
--
作者：
Leritz EC;McGlinchey RE;Salat DH;Milberg WP
我们研究了血清胆固醇是脑血管疾病(CVD)的既定危险因素，如何与没有神经学或CVD病史的健康中老年人的认知功能有关。从120名年龄在43-85岁之间的人群中获得了一个完整的脂类小组，这些人也接受了全面的神经心理学检查。为了减少变量的数量，并从经验上确定广泛的认知领域，神经心理测试的分数被提交到因素分析中。这项分析揭示了三个可解释的因素：记忆、执行功能和记忆/语言。使用个人胆固醇指标(总胆固醇、低密度脂蛋白、低密度脂蛋白、高密度脂蛋白、高密度脂蛋白和甘油三酯)以及年龄、教育程度、用药状况(降脂剂)、载脂蛋白E状态和心血管疾病的其他危险因素进行了三个独立的分层多元回归分析，以预测神经心理功能。记忆因素通过年龄、低密度脂蛋白和甘油三酯水平的组合来预测；年龄和甘油三酯都与因素得分负相关，而低密度脂蛋白水平显示正相关。执行力和记忆力/语言因素都只能通过教育来解释，即年龄越长，表现越好。这些结果证明，个体胆固醇、脂蛋白和甘油三酯对认知功能的影响可能不同，超过了其他常见的心血管疾病危险因素和载脂蛋白E状态。我们的发现证明了在认知老化研究中考虑血管风险因素的重要性，例如胆固醇。
We examined how serum cholesterol, an established risk factor for cerebrovascular disease (CVD), relates to cognitive function in healthy middle-older aged individuals with no neurologic or CVD history. A complete lipid panel was obtained from a cohort of one hundred twenty individuals, ages 43–85, who also underwent a comprehensive neuropsychological examination. In order to reduce the number of variables and empirically identify broad cognitive domains, scores from neuropsychological tests were submitted into a factor analysis. This analysis revealed three explainable factors: Memory, Executive Function and Memory/Language. Three separate hierarchical multiple regression analyses were conducted using individual cholesterol metrics (total cholesterol, low density lipoprotein; LDL, high density lipoprotein; HDL, and triglycerides), as well as age, education, medication status (lipid lowering agents), ApoE status, and additional risk factors for CVD to predict neuropsychological function. The Memory Factor was predicted by a combination of age, LDL, and triglyceride levels; both age and triglycerides were negatively associated with factor score, while LDL levels revealed a positive relationship. Both the Executive and Memory/Language factor were only explained by education, whereby more years were associated with better performance. These results provide evidence that individual cholesterol lipoproteins and triglycerides may differentially impact cognitive function, over and above other common CVD risk factors and ApoE status. Our findings demonstrate the importance of consideration of vascular risk factors, such as cholesterol, in studies of cognitive aging.