Spatio-temporally-complex concentration profiles using a tunable chaotic micromixer
Spatio-temporally-complex concentration profiles using a tunable chaotic micromixer
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DOI：
10.1063/1.2358194
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发表时间：
2006-10-02
影响因子：
4
通讯作者：
Folch, Albert
中科院分区：
文献类型：
--
作者：
Hsu, Chia-Hsien;Folch, Albert
向细胞呈现在空间和时间上变化的刺激的能力是对动态过程（如细胞迁移、生长、适应和分化）的机械理解的关键。存在输出多个浓度的给定化合物的微流体梯度装置，但是改变输出通常需要改变流速，这可能在生物测量中混淆和/或对于高通量应用不切实际。我们提出了混沌混合器，产生多个，复杂的浓度梯度，可以在时间上平稳变化，而不会显着改变流速。(c)2006年，美国物理学会。
The ability to present cells with stimuli that vary in space and time is key for a mechanistic understanding of dynamic processes such as cell migration, growth, adaptation, and differentiation. Microfluidic gradient devices that output multiple concentrations of a given compound exist, but changing the output generally requires a change in flow rates that can be confounding in biological measurements and/or impractical for high-throughput applications. We present chaotic mixers that generate multiple, complex concentration gradients that can be smoothly varied in time without significantly altering the flow rate. (c) 2006 American Institute of Physics.