Effects of exercise training on physical impairment, arterial stiffness and health-related quality of life in patients with chronic kidney disease: a pilot study
Effects of exercise training on physical impairment, arterial stiffness and health-related quality of life in patients with chronic kidney disease: a pilot study
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DOI：
10.1007/s11255-010-9823-7
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发表时间：
2011-12-01
影响因子：
2
通讯作者：
Manns, Braden
中科院分区：
文献类型：
--
作者：
Mustata, Stefan;Groeneveld, Sharon;Manns, Braden
慢性肾脏病（CKD）患者体力活动能力受损，健康相关生活质量降低，心血管疾病发病率和死亡率较高。中等强度运动已被证明可以为健康个体和无CKD患者提供心血管和代谢益处。长期的运动训练被推荐为许多慢性疾病管理的重要组成部分。这项随机对照的试验性项目研究了运动对透析前CKD患者的影响。10名患者随机接受12个月的运动（EX），10名接受标准治疗（CT）。比较两组患者在肢体功能障碍方面的差异（VO 2峰值和耐受时间[ET]），动脉僵硬度（增强指数[AI]）和健康相关生活质量（EuroQol EQ-5D和简表-36份问卷）（均在基线和12个月时测量）。对于VO 2峰值，EX和CT之间的差异具有统计学意义（3.59 ml O-2/kg/min; 95% CI 0.92，6.26; P = 0.01）、ET（10.97 min; 95% CI 4.34，17.59; P = 0.003）和AI（-11.7%; 95% CI-18.79，-4.61; P = 0.003）。在EQ-5D和SF-36中观察到具有临床意义的变化。本研究表明，长期运动训练可改善透析前CKD患者的身体损害、动脉僵硬度和健康相关生活质量。需要进行一项更大规模的随机试验，以检查运动对透析前CKD患者心血管风险标志物和生活质量的影响。
Patients with chronic kidney disease (CKD) have impaired performance in physical tasks, lower health-related quality of life and high cardiovascular morbidity and mortality. Moderate intensity exercise has been shown to provide cardiovascular and metabolic benefits in healthy individuals and patients without CKD. Long-term exercise training is recommended as a vital component in the management of a number of chronic diseases. This randomized controlled pilot project examined the effects of exercise in predialysis CKD patients.Ten patients were randomized to 12 months of exercise (EX) and 10 to standard care (CT). We compared the difference between the two groups in physical impairment (VO2peak and endurance time [ET]), arterial stiffness (augmentation index [AI]) and health-related quality of life (EuroQol EQ-5D and Short Form-36 questionnaires) (all measured at baseline and 12 months).The difference between EX and CT was statistically significant for VO2peak (3.59 ml O-2/kg/min; 95% CI 0.92, 6.26; P = 0.01), ET (10.97 min; 95% CI 4.34, 17.59; P = 0.003) and AI (-11.7%; 95% CI -18.79, -4.61; P = 0.003). Clinically important changes were noted in EQ-5D and SF-36.This study suggests that long-term exercise training improves physical impairment, arterial stiffness and health-related quality of life in patients with predialysis CKD. A larger randomized trial is required to examine the impact of exercise on markers of cardiovascular risk and quality of life in predialysis CKD patients.