Pursuit-related neurons in the supplementary eye fields: Discharge during pursuit and passive whole body rotation
Pursuit-related neurons in the supplementary eye fields: Discharge during pursuit and passive whole body rotation
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DOI：
10.1152/jn.01128.2003
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发表时间：
2004-06-01
影响因子：
2.5
通讯作者：
Fukushima, K
中科院分区：
文献类型：
--
作者：
Fukushima, J;Akao, T;Fukushima, K
灵长类动物的额叶皮层包含两个与平滑追逐相关的区域：额叶视野（FEFs）和辅助视野（SEFs）。为了区分SEFs在追逐中的具体作用，我们检查了总共89个追逐相关神经元的放电，这些神经元在头部稳定的日本猴子追逐在额平行平面和/或深度上正弦移动的点时，无论有无被动全身旋转，都显示出一致的调制。在不同频率的平滑追逐过程中，43%的神经元（17/40）表现出与眼速度线性相关的调制放电幅度。在完全黑暗的前庭-眼反射和/或椅子旋转被取消时，大多数被测试的神经元（91% = 30/33）有反应。然而，只有17%的响应神经元（4/30）在追逐-前庭交互过程中与凝视（眼在空间）速度成比例调节。当猴子盯着一个固定的点时，20%的神经元（7/34）对第二个点的运动做出反应。在同时进行平滑追踪和收敛跟踪的神经元（n = 56）中，27%（15/56）的神经元在两种情况下都放电，62%（35/56）的神经元仅在平滑追踪时有反应，11%（6/56）的神经元仅在收敛跟踪时有反应。在追求过程中，反应神经元的相移（相对于刺激速度）在额位面和深度面以及椅子旋转过程中几乎保持不变（小于或等于1hz）。这些结果，加上大多数SEF神经元的前庭相关放电，表明在相同的任务条件下，大多数SEF追求相关神经元的放电与尾侧FEF神经元的放电完全不同，这表明这两个区域参与了追求-前庭相互作用的不同方面，包括预测性追求。
The primate frontal cortex contains two areas related to smooth-pursuit: the frontal eye fields (FEFs) and supplementary eye fields (SEFs). To distinguish the specific role of the SEFs in pursuit, we examined discharge of a total of 89 pursuit-related neurons that showed consistent modulation when head-stabilized Japanese monkeys pursued a spot moving sinusoidally in fronto-parallel planes and/or in depth and with or without passive whole body rotation. During smooth-pursuit at different frequencies, 43% of the neurons tested (17/40) exhibited discharge amplitude of modulation linearly correlated with eye velocity. During cancellation of the vestibulo-ocular reflex and/or chair rotation in complete darkness, the majority of neurons tested (91% = 30/33) responded. However, only 17% of the responding neurons (4/30) were modulated in proportion to gaze (eye-in-space) velocity during pursuit-vestibular interactions. When the monkeys fixated a stationary spot, 20% of neurons tested (7/34) responded to motion of a second spot. Among the neurons tested for both smooth-pursuit and vergence tracking (n = 56), 27% (15/56) discharged during both, 62% (35/56) responded during smooth-pursuit only, and 11% (6/56) during vergence tracking only. Phase shifts ( relative to stimulus velocity) of responding neurons during pursuit in frontal and depth planes and during chair rotation remained virtually constant (less than or equal to1 Hz). These results, together with the robust vestibular-related discharge of most SEF neurons, show that the discharge of the majority of SEF pursuit-related neurons is quite distinct from that of caudal FEF neurons in identical task conditions, suggesting that the two areas are involved in different aspects of pursuit-vestibular interactions including predictive pursuit.