Prevalence and characteristics of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus nasal colonization among a community-based diabetes population in Foshan, China.
Prevalence and characteristics of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus nasal colonization among a community-based diabetes population in Foshan, China.
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DOI：
10.1111/jdi.12591
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发表时间：
2017-05
影响因子：
3.2
通讯作者：
Yao Z
中科院分区：
文献类型：
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作者：
Lin J;Xu P;Peng Y;Lin D;Ou Q;Zhang T;Bai C;Ye X;Zhou J;Yao Z
有证据表明，糖尿病可能会导致社区环境中金黄色葡萄球菌（S. aureus）和耐甲氧西林金黄色葡萄球菌（MRSA）的定植增加。我们进行了一项横断面研究，以确定社区糖尿病人群中金黄色葡萄球菌和 MRSA 鼻定植的流行率和影响因素，并确定分离菌株的特征。该研究共有来自 11 个社区的 956 名参与者。在 529 名糖尿病参与者中，46 名被金黄色葡萄球菌定植，22 名被 MRSA 定植。在 427 名非糖尿病参与者中，25 名被金黄色葡萄球菌定植，12 名被 MRSA 定植。男性（比值比 0.45，95% 置信区间 0.20-0.99，P = 0.047）金黄色葡萄球菌鼻腔定植的可能性较小，而糖尿病人群中血糖控制良好的人群（比值比 2.04，95% 置信区间 1.01-4.13，P = 0.047）更可能有金黄色葡萄球菌鼻腔定植。糖尿病人群中多重耐药金黄色葡萄球菌菌株比例（52.17%）高于非糖尿病人群（28.00%；χ2=3.848，P=0.050）。糖尿病人群中最常见的MRSA克隆复合体型和葡萄球菌染色体盒mec型分别是克隆复合体5型（40.91%）和IV型（27.27%）。 MRSA菌株中潘顿-瓦伦丁杀白细胞素基因的比例为17.65%。 MRSA 菌株存在很大的序列类型多样性。社区糖尿病人群中MRSA的患病率中等，但糖尿病人群中耐多药金黄色葡萄球菌菌株的比例较高，分子特征多样，值得关注。
Evidence suggests that diabetes might cause an increase in colonization of Staphylococcus aureus (S. aureus) and methicillin‐resistant S. aureus (MRSA) in community settings. We carried out a cross‐sectional study to determine the prevalence and influencing factors of S. aureus and MRSA nasal colonization among a community‐based diabetes population, and to identify the characteristics of the isolated strains. A total of 956 participants from 11 community settings were included in the study. Of the 529 diabetes participants, 46 were colonized with S. aureus and 22 were colonized with MRSA. Of the 427 non‐diabetes participants, 25 were colonized with S. aureus and 12 were colonized with MRSA. Men (odds ratio 0.45, 95% confidence interval 0.20–0.99, P = 0.047) were less likely to have S. aureus nasal colonization, and those with well‐controlled blood glucose (odds ratio 2.04, 95% confidence interval 1.01–4.13, P = 0.047) among the diabetes population were more likely to have S. aureus nasal colonization. The proportion of multidrug‐resistant S. aureus strains in the diabetes population (52.17%) was higher than that in the non‐diabetes population (28.00%; χ2 = 3.848, P = 0.050). The most common clonal complex type and Staphylococcal chromosome cassette mec type of MRSA in diabetes population was clonal complex 5 (40.91%) and type IV (27.27%), respectively. The proportion of Panton–Valentine leukocidin gene in MRSA strains was 17.65%. There was great sequence type diversity in MRSA strains. The prevalence of MRSA in the community‐based diabetes population was moderate, and the high proportions of multidrug‐resistant S. aureus strains and diverse molecular characteristics in the diabetes population should be noticed.