Prospective association between the dietary inflammatory index and metabolic syndrome: Findings from the SU.VI.MAX study
Prospective association between the dietary inflammatory index and metabolic syndrome: Findings from the SU.VI.MAX study
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DOI：
10.1016/j.numecd.2015.09.002
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发表时间：
2015-11-01
影响因子：
3.9
通讯作者：
Kesse-Guyot, E.
中科院分区：
文献类型：
--
作者：
Neufcourt, L.;Assmann, K. E.;Kesse-Guyot, E.
背景和目的：代谢综合征（MetS）的预防是主要关注的问题，营养已被证明至少可以部分调节代谢综合征的风险。我们的目的是在一大批法国成年人中调查促炎饮食是否与MetS及其组成部分的高风险相关。方法和结果：本研究共纳入了3726名来自维生素和矿物质抗氧化剂补充（SU.VI.MAX）队列的参与者。在基线和13年随访后，使用自我报告的药物、临床调查数据和生物学测量确定MetS状态。采用重复24 h饮食记录（n = 10.1 +/- 3.1）计算饮食炎症指数（DII）。采用Logistic和线性回归分析来评估DII（以Q为单位，四分位数）与MetS发病率以及有助于MetS定义的特征（血压、血糖、甘油三酯、高密度脂蛋白胆固醇、腰围）的前瞻性关联。具有促炎特性的饮食，如较高的DII评分所表达的，与发生MetS的高风险显着相关（第四季度与第一季度比较的OR: 1.39, 95%置信区间为1.01-1.92,P = 0.047）。此外，较高的DII评分与较高的收缩压和舒张压（四分位数的p趋势分别为0.03和0.05）和甘油三酯（p趋势= 0.01）以及较低的hdl -胆固醇（p趋势= 0.03）相关。结论：较高的DII评分与较高的MetS风险相关，并与血压、甘油三酯和高密度脂蛋白胆固醇相关。促进具有抗炎特性的健康饮食可能有助于预防心脏代谢紊乱。(C) 2015意大利糖尿病学会、意大利动脉粥样硬化研究学会、意大利人类营养学会、费德里科二世大学临床医学与外科学系。Elsevier B.V.版权所有。
Background and aims: The prevention of the metabolic syndrome (MetS) is of major concern and nutrition has been shown to modulate at least partly MetS risk. Our objective was to investigate whether a pro-inflammatory diet was associated with a higher risk of MetS and its components in a large cohort of French adults.Methods and results: A total of 3726 participants from the Supplementation en Vitamines et Mineraux AntioXydants (SU.VI.MAX) cohort were included in this study. The MetS status was identified at baseline and after 13 years of follow-up using self-reported medication, data from clinical investigations and biological measurements. The dietary inflammatory index (DII) was computed using repeated 24 h-dietary records (n = 10.1 +/- 3.1). Logistic and linear regression analyses were conducted to assess the prospective association of the DII (as Q, quartiles) with the incidence of MetS and with the traits contributing to the MetS-definition (blood pressure, glycaemia, triglycerides, HDL-cholesterol, waist circumference).A diet with pro-inflammatory properties, as expressed by higher DII scores, was significantly associated with a higher risk of developing the MetS (OR comparing Q4 to Q1: 1.39, 95% confidence interval 1.01-1.92, P = 0.047). Moreover, higher DII scores were associated with higher systolic and diastolic blood pressure (P-trend across quartiles = 0.03 and 0.05, respectively) and triglycerides (P-trend = 0.01), and with lower HDL-cholesterol (P-trend = 0.03).Conclusion: A higher DII score was prospectively associated with a higher risk of MetS, with associations with blood pressure, triglycerides and HDL-cholesterol. Promotion of a healthy diet exhibiting anti-inflammatory properties may contribute to prevent cardio-metabolic disorders. (C) 2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.