Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin
Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin
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DOI：
10.1016/s0940-9602(03)80030-4
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发表时间：
2003-06-01
影响因子：
2.2
通讯作者：
Dubovy, P
中科院分区：
文献类型：
--
作者：
Haninec, P;Houst'ava, L;Dubovy, P
脊神经根撕脱伤导致相应脊髓节段运动神经元的丢失。在本实验中，我们已经测试了胰岛素样生长因子-I（IGF-I）和脑活素对撕脱的运动神经元的存活后，其慢性鞘内给药的成年大鼠。我们发现，C5前根撕脱导致同一脊髓节段运动神经元的显著丢失，主要是由于细胞凋亡。与未处理的对照组大鼠相比，鞘内注射IGF-I或脑活素4周后，撕脱前角运动神经元存活量显著升高。在我们的实验模型中，IGF-I和脑活素的作用之间没有观察到显着差异。结果表明，IGF-I和脑活素都可以减少撕脱伤引起的成年大鼠运动神经元的丢失。
Ventral root avulsion results in the loss of motoneurons in the corresponding spinal cord segment. In the present experiments we have tested effects of insulin-like growth factor-I (IGF-I) and Cerebrolysin on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats. We have found that avulsion of the C5 ventral roots results in significant loss of motoneurons in the same spinal cord segment due mainly to apoptosis. In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of IGF-I or Cerebrolysin. No significant differences were observed between effects of IGF-I and Cerebrolysin in our experimental model. The results suggest that both IGF-I and Cerebrolysin can reduce avulsion-induced loss of adult rat motoneurons.