Lymphoid-specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression
Lymphoid-specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression
复制标题
淋巴特异性解旋酶通过转录调控着丝粒蛋白F表达促进肝细胞癌的生长和侵袭
DOI：
10.1111/cas.14037
复制
发表时间：
2019-07-01
期刊：
影响因子：
5.7
通讯作者：
Cai，Jia-Bin
中科院分区：
文献类型：
--
作者：
Yang，Xuan;Miao，Bi-Si;Cai，Jia-Bin
类肉瘤特异性解旋酶（LSH）在肿瘤组织中过表达，其过表达与几种癌症的预后不良相关。然而，LSH在肝细胞癌（HCC）中的作用和分子机制仍不清楚。在此，我们报告LSH在HCC的肿瘤组织中过表达，并且LSH的过表达与公共HCC数据库中的不良预后相关，并通过我们部门的临床样本进行了验证。LSH的异位表达促进了肝癌细胞在体内和体外的生长。LSH过表达通过激活着丝粒蛋白F（CENPF）的转录促进肿瘤生长。临床上，LSH和/或CENPF的过度表达与HCC的总生存期较短和累积复发率较高相关。总之，LSH通过转录调控CENPF的表达促进HCC的肿瘤生长。因此，LSH可能是一个新的预测预后的指标和一个潜在的治疗肝癌的靶点。
Lymphoid‐specific helicase (LSH) is overexpressed in tumor tissues and its overexpression is associated with poor prognosis in several cancers. However, the role and molecular mechanism of LSH in hepatocellular carcinoma (HCC) remains largely unknown. Herein, we report that LSH was overexpressed in tumor tissues of HCC, and overexpression of LSH was associated with poor prognosis from a public HCC database, and validated by clinical samples from our department. Ectopic LSH expression promoted the growth of HCC cells in vivo and in vitro. Mechanistically, LSH overexpression promoted tumor growth by activating transcription of centromere protein F (CENPF). Clinically, overexpression of LSH and/or CENPF correlated with shorter overall survival and higher cumulative recurrence rates of HCC. In conclusion, LSH promotes tumor growth of HCC through transcriptional regulation of CENPF expression. Therefore, LSH may be a novel predictor for prognosis and a potential therapeutic target for HCC.