Loss of functional prion protein: A role in prion disorders?
Loss of functional prion protein: A role in prion disorders?
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DOI：
10.1016/s1074-5521(96)90128-3
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发表时间：
1996-08-01
影响因子：
--
通讯作者：
Sisodia, SS
中科院分区：
文献类型：
--
作者：
Borchelt, DR;Sisodia, SS
为了了解朊病毒蛋白（PrP）的正常功能及其在朊病毒疾病中的作用，几个研究小组培育了缺乏PrP的小鼠。其中一些小鼠出现与朊病毒疾病相关的症状，但其他实验证据表明，功能性PrP的丧失并不是这些疾病的诱发因素。
To understand the normal function of the prion protein (PrP) and its role in prion disorders, several groups have generated mice lacking PrP. Some of these mice develop symptoms associated with prion diseases, but other experimental evidence suggests that the loss of functional PrP is not the instigating factor in these disorders.