Constipation triggered the malignant syndrome in Parkinson's disease
Constipation triggered the malignant syndrome in Parkinson's disease
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DOI：
10.1007/s10072-011-0710-5
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发表时间：
2012-04-01
影响因子：
3.3
通讯作者：
Tateno, Fuyuki
中科院分区：
文献类型：
--
作者：
Ogawa, Emina;Sakakibara, Ryuji;Tateno, Fuyuki
一名69岁的慢性便秘帕金森病患者同时出现粪便嵌塞和恶性综合征，即使患者正在按处方服用抗帕金森病药物。给予静脉注射左旋多巴和口服具有肾上腺素能5-HT 3受体激动剂特性的草药大肯珠头，成功地改善了他的临床症状。帕金森病的发生可能与左旋多巴的吸收有关。此外，改善的肠蠕动可以防止帕金森病的恶化和恶性综合征的发生。
A 69-year-old, chronically constipated patient with Parkinson's disease developed fecal impaction and the malignant syndrome simultaneously, even while the patient was taking anti-parkinsonian drugs as prescribed. Administration of intravenous levodopa and oral Dai-kenchu-tou, an herbal medicine with serotonergic 5-HT3 receptor agonistic property successfully ameliorated his clinical symptoms. Constipation may trigger worsening of Parkinson's disease and occurrence of the malignant syndrome by affecting levodopa absorption. Further, improved bowel motility may prevent worsening of Parkinson's disease and occurrence of the malignant syndrome.