Inhibition of growth of human breast carcinoma xenografts by energy expenditure via voluntary exercise in athymic mice fed a high-fat diet.
Inhibition of growth of human breast carcinoma xenografts by energy expenditure via voluntary exercise in athymic mice fed a high-fat diet.
复制标题
通过高脂饮食喂养的无胸腺小鼠自愿运动的能量消耗来抑制人乳腺癌异种移植物的生长。
DOI：
10.1080/01635589509514385
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Welsch,CW
中科院分区：
文献类型：
--
作者：
Welsch,MA;Cohen,LA;Welsch,CW
本研究的目的是通过自愿运动来评估能量消耗对胸腺裸鼠体内人类乳腺癌异种移植物生长的影响。久坐和运动携带MDA - MB231人类乳腺癌皮下移植物的胸腺裸小鼠每天以低于自由量10%的纯度高脂肪饮食喂养，以确保每只久坐和运动小鼠的饮食（能量）消耗相同。久坐的老鼠和运动的老鼠被单独饲养；此外，运动小鼠可以使用活动轮（每天24小时）。在五周的时间内评估人类乳腺癌的生长（癌体积）。在五周的时间内，单个小鼠的平均跑步活动范围为每天<1至7.9英里。人类乳腺癌的生长与每只小鼠每天跑步的平均英里数呈显著负相关（p < 0.018）。将这些小鼠分为两组，即平均2.7-4.7英里/天和平均bb0 - 4.7英里/天，前者的癌症增长率为83% (p = 0.305)，后者为59% （p = 0.039）。这些结果提供了证据，通过自愿使用活动轮的能量消耗，可以显著减少胸腺裸鼠维持的人类乳腺癌的生长。
The purpose of this study was to assess the effect of energy expenditure, via voluntary exercise, on growth of xenografts of human breast carcinomas in athymic nude mice. Sedentary and exercising athymic nude mice bearing subcutaneous grafts of MDA‐MB231 human breast carcinomas were fed daily a purified high‐fat diet at 10% less than ad libitum to ensure an equal quantity of diet (energy) consumption for each sedentary and exercising mouse. The sedentary and exercising mice were housed singly; the exercising mice had, in addition, access to an activity wheel (24 hrslday). Growth of human breast carcinomas (carcinoma volumes) was evaluated during a five‐week period. Mean running activities of individual mice over the five‐week period ranged from <1 to 7.9 miles/day. Growth of the human breast carcinomas was significantly inversely correlated with the mean number of miles that each mouse ran per day (p < 0.018). Upon separation of these mice into two running groups, i.e., those that averaged 2.7—4.7 miles/day and those that averaged>4.7 miles/day, carcinoma growth was 83% of sedentary controls in the former group (p = 0.305) and 59% of sedentary controls in the latter group (p = 0.039). These results provide evidence that energy expenditure, via voluntary use of an activity wheel, can reduce significantly the growth of human breast carcinomas maintained in athymic nude mice.