The effect of chronic ethanol consumption on the tumorigenicity of N-nitrosopyrrolidine in male Syrian golden hamsters.
The effect of chronic ethanol consumption on the tumorigenicity of N-nitrosopyrrolidine in male Syrian golden hamsters.
复制标题
慢性乙醇消耗对雄性叙利亚金仓鼠 N-亚硝基吡咯烷致瘤性的影响。
DOI：
10.1016/0304-3835(86)90019-4
复制
发表时间：
1986
期刊：
影响因子：
9.7
通讯作者：
Furuya,K
中科院分区：
文献类型：
--
作者：
McCoy,GD;Hecht,SS;Furuya,K
The effect of oral administration of ethanol on the tumorigenicity of N-nitrosopyrrolidine (NPYR) in chow-fed male Syrian golden hamsters has been investigated. Groups of hamsters were given tap water, 7.4% ethanol or 18.5% ethanol—water mixtures 4 weeks prior to and throughout the carcinogen administration period. A total dose of 1 mmol NPYR was administered by intraperitoneal injection to both tap water and ethanol-consuming animals over a 25-week period. Twenty-four hours after the last injection, ethanol-consuming animals were returned to tap water. In control animals treated with NPYR we observed 3 26 animals with tracheal papillomas, and 6 26 animals with hepatic neoplastic nodules. In animals receiving 7.4% ethanol—water mixtures, we observed 6 26 tracheal papillomas, and 17 26 hepatic neoplastic nodules. Similar results were observed in animals receiving 18.5% ethanol. These data indicate that chronic administration of ethanol to chow-fed hamsters increases the incidence of hepatic neoplastic nodules although no differences in the two levels of ethanol were observed.
