OUTCOME OF LOW-BIRTH-WEIGHT
OUTCOME OF LOW-BIRTH-WEIGHT
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DOI：
10.1159/000184197
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发表时间：
1994-01-01
期刊：
影响因子：
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通讯作者：
BARKER, DJP
中科院分区：
文献类型：
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作者：
BARKER, DJP
现在已知，出生时和婴儿期身材矮小的婴儿在成年后患冠心病、高血压和糖尿病的风险增加。这导致了这样的建议，即这些疾病是由子宫内或出生后立即供应的营养或氧气不足而“编程”的。“编程”现象，即生命早期的营养不良永久性地改变了身体结构和功能，在动物中得到了很好的证明。到目前为止，我们对引起这种疾病的细胞和分子变化所知甚少，但激素分泌或组织对激素敏感性的持续变化，在确定成人疾病方面可能是重要的。
Babies who are small at birth and during infancy are now known to be at an increased risk of developing coronary heart disease, hypertension and diabetes during adult life. This has led to the suggestion that these diseases are 'programmed' by an inadequate supply of nutrients or oxygen in utero or immediately after birth. The phenomenon of 'programming', whereby undernutrition in early life permanently changes body structure and function, is well documented in animals. As yet we know little about cellular and molecular changes which underlie it, but persisting changes in the secretion of hormones or in the sensitivity of tissues to them may be important in determining adult disease.