Prefrontal dysfunction in remitted depression at work reinstatement using near-infrared spectroscopy
Prefrontal dysfunction in remitted depression at work reinstatement using near-infrared spectroscopy
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DOI：
10.1016/j.pscychresns.2013.07.009
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发表时间：
2013-12-30
影响因子：
2.3
通讯作者：
Hirayasu, Yoshio
中科院分区：
文献类型：
--
作者：
Ikeda, Eiji;Shiozaki, Kazumasa;Hirayasu, Yoshio
在工业化国家，由于抑郁症导致的长期和/或复发性疾病缺勤一直是一个重要的健康问题。此外，以前的病假也是复发的一个风险因素。然而，许多特征，特别是生物学方面，尚未调查缓解抑郁症患者谁准备返回工作，从病假。因此，本研究的目的是澄清的病理生理学特征的患者谁是在复发的疾病缺席的风险。我们招募了21名患者和16名健康对照受试者。所有病人都准备在一个月内从长期病假中恢复工作。所有受试者进行了检查，前额叶功能的语言流畅性任务（VET）和Stroop任务，使用近红外光谱的oxyHb的变化。与对照组相比，患者组在VFT中的前额叶反应被抑制，在Stroop任务中的前额叶反应增加。显着延长的反应时间，观察到在不一致的条件下，在患者组的Stroop任务抑郁症患者表现出受损的执行功能的Stroop任务和前额叶功能障碍，尽管临床缓解。残留的前额功能障碍可能是反复生病缺勤的一个生物学原因。(C)2013爱思唯尔爱尔兰有限公司保留所有权利。
A long-term and/or recurrent sickness absence from work due to depression has been an important health problem in industrial countries. In addition, previous sick leave is a risk factor of recurrence. However, many characteristics, especially biological aspects, have not been investigated in remitted depressive patients who were ready to return to work from sickness absence. Therefore, the purpose of this study is to clarify the pathophysiological characteristics of patients who were at risk for recurrence of sickness absence. We recruited 21 patients and 16 healthy control subjects. All patients were ready to return to work within one month from long-term sickness absence. All subjects were examined for prefrontal function represented by oxyHb changes during the verbal fluency task (VET) and the Stroop task using near-infrared spectroscopy. Suppressed prefrontal reaction during the VFT and increased prefrontal reaction during the Stroop task were observed in the patient group compared with the control group. Significantly lengthened reaction time was observed in the incongruent condition in the patient group during the Stroop task Depressive patients showed impaired executive function measured by the Stroop task and had prefrontal dysfunction despite clinical remission. Residual prefrontal dysfunction may be one biological reason for repetitive sickness absence. (C) 2013 Elsevier Ireland Ltd. All rights reserved.