Predictors for Short-Term Efficacy of Allergen-Specific Sublingual Immunotherapy in Children with Allergic Rhinitis
Predictors for Short-Term Efficacy of Allergen-Specific Sublingual Immunotherapy in Children with Allergic Rhinitis
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DOI：
10.1155/2020/1847061
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发表时间：
2020-04-21
影响因子：
4.6
通讯作者：
Luo, Renzhong
中科院分区：
文献类型：
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作者：
Liu, Wenlong;Zeng, Qingxiang;Luo, Renzhong
背景：在过敏原特异性舌下免疫治疗(SIT)中，良好的依从性通常来自良好的短期疗效。我们的目的是评估可以预测儿童缝隙手术近期临床疗效的预处理参数。方法：研究方法。517例接受切开手术的变应性鼻炎(AR)儿童被纳入本研究。收集基线临床特征和实验室参数，并通过症状和用药评分评估临床疗效。建立多元Logistic回归模型和受试者工作特征(ROC)曲线。结果。在接受SIIT治疗的466名儿童中，共有303名(65%)取得了短期临床疗效。使用空调时间与临床疗效呈负相关，而血清S-IgE、血清IL-10、IL-35水平及S-IgE/总-IgE比值与临床疗效呈正相关。结论。使用空调时间、血清特异性免疫球蛋白(S-IgE)、血清IL-10、IL-35水平及S-IgE/总-IgE的比值对儿童的选择有一定的参考价值。
Background.A good compliance in allergen-specific sublingual immunotherapy (SLIT) often comes from good short-term efficacy. We aimed to evaluate the pretreatment parameters which can predict the short-term clinical efficacy in children that underwent SLIT. Methods. 517 children with allergic rhinitis (AR) that underwent SLIT were recruited in this study. Baseline clinical characteristics and laboratory parameters were collected, and the clinical efficacy was evaluated using symptom and medication scores. A multivariate logistic regression model and receiver operating characteristic (ROC) curves were established. Results. A total of 303 (65%) in 466 children that underwent SLIT achieved short-term clinical efficacy. The time of using the air conditioner was negatively correlated with clinical efficacy, whereas the serum-specific IgE (s-IgE) levels, the serum IL-10 and IL-35 levels, and the s-IgE/total-IgE ratio were positively correlated with clinical efficacy. Conclusion. The time of using the air conditioner, serum-specific IgE (s-IgE) levels, serum IL-10 and IL-35 levels, and s-IgE/total-IgE ratio may be helpful for child selection before SLIT.