Malignant transformation of an intracranial germinoma into a choriocarcinoma
Malignant transformation of an intracranial germinoma into a choriocarcinoma
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颅内生殖细胞瘤恶变为绒毛膜癌
DOI：
10.1136/bcr.12.2008.1351
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发表时间：
2009
期刊：
影响因子：
0.9
通讯作者：
H. Yatsushige
中科院分区：
文献类型：
--
作者：
S. Takeuchi;Y. Takasato;H. Masaoka;T. Hayakawa;N. Otani;Y. Yoshino;H. Yatsushige
颅内纯生殖细胞瘤作为不同组织学类型的生殖细胞肿瘤，其复发或转移的报道很少。本报告涉及文献中的第一例颅内复发的生殖细胞瘤转化为绒毛膜癌。17岁男性，头痛病史1个月。MRI显示在松果体和鞍上区有均匀增强的肿块。肿瘤被切除，组织学检查确定为纯粹的生殖细胞瘤。切除后，患者接受化疗和放疗，肿块消失。5年零5个月后，患者出现恶心和头痛，并在左侧脑室发现肿瘤复发。肿瘤被切除，组织学诊断为绒毛膜癌。患者接受了化疗和放疗，但1个月后因播散死亡。没有进行尸检。
The recurrence or metastasis of intracranial pure germinomas as germ cell tumours of different histological types has rarely been reported. The present report concerns the first case in the literature of intracranial recurrence of a germinoma transformed into a choriocarcinoma. A 17-year-old man presented with a 1 month history of headache. MRI revealed a homogeneously enhanced mass within the pineal and suprasellar regions. The tumour was resected, and histological examination identified it as a pure germinoma. After resection, the patient underwent chemotherapy and radiotherapy and the mass disappeared. At 5 years and 5 months later, the patient presented with nausea and headache, and recurrence of the tumour was revealed in the left lateral ventricle. The tumour was resected and histological diagnosis identified it as a choriocarcinoma. The patient was treated with chemotherapy and radiotherapy, but died due to dissemination 1 month later. An autopsy was not performed.