Absorption, Distribution and Excretion of Four Forms of Titanium Dioxide Pigment in the Rat
Absorption, Distribution and Excretion of Four Forms of Titanium Dioxide Pigment in the Rat
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DOI：
10.1111/1750-3841.13791
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发表时间：
2017-08-01
影响因子：
3.9
通讯作者：
Magnuson, Berna
中科院分区：
文献类型：
--
作者：
Farrell, Thomas P.;Magnuson, Berna
二氧化钛(二氧化钛)是一种白色添加剂，在全球范围内获得批准并在食品中使用已有很长的历史。然而，对于用于非色素应用的新型、工程、纳米形式的二氧化钛的生物效应是否适用于口腔暴露于食品级二氧化钛颜料的安全性，存在相当大的困惑。本研究旨在探讨大鼠口服食品级二氧化钛后的吸收、分布和排泄途径。4种不同等级的二氧化钛(200ppm)和对照(0ppm)饲料连续喂养大鼠7d，然后分别饲喂对照饲料1、24和72h。大鼠肝脏、肾脏和肌肉中钛的浓度主要低于检测限(P<0.05)。
Titanium dioxide (TiO2) is a white color additive that has a long history of global approval and use in food. There is, however, considerable confusion regarding the applicability of the biological effects of novel, engineered, nano-sized forms of TiO2 developed for nonpigmentary applications to the safety of oral exposure to food grade TiO2 pigment. The objective of this study was to assess the absorption, distribution, and routes of excretion in rats after oral exposure to food grade TiO2.Four different grades of TiO2 (200 ppm) or control (0 ppm) diets were fed to rats for 7 consecutive days, followed by control diet only for 1, 24, or 72 h.Concentrations of titanium in liver, kidney and muscle were mainly below the limit of detection (