alpha-Noradrenergic potentiation of neurotransmitter-stimulated cAMP production in rat striatal slices.
alpha-Noradrenergic potentiation of neurotransmitter-stimulated cAMP production in rat striatal slices.
复制标题
大鼠纹状体切片中神经递质刺激的 cAMP 产生的 α-去甲肾上腺素能增强。
DOI：
10.1016/0006-8993(84)91452-5
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发表时间：
1984
期刊：
影响因子：
2.9
通讯作者：
Ciaranello,RD
中科院分区：
文献类型：
--
作者：
Leblanc,GG;Ciaranello,RD
The present study examines the possible involvement of α-adrenergic receptors in catecholamine-stimulated cAMP production in intact slices of rat striatum. Norepinephrine (NE) produces a greater stimulation of cAMP levels than does the ß-adrenergic agonist, isoprotererenol (ISO), and the NE response is inhibited by both the ß-adrenergic antagonist, propranolol, and the α-adrenergic antagonist, phentolamine. The α-adrenergic agonist, 6-fluoronorepinephrine (6-FNE), has little or no effec on basal cAMP levels; however, 6-FNE causes a marked potentiation of the cAMP responses to ISO. Hence, NE stimulation of cAMP levels in striatal slices appears to involve a synergistic interaction between α- and ß-adrenergic receptors.α-Receptors also potentiate adenosine stimulation of cAMP levels in striatal slices. However, in contrast to results previously reported in cerebral cortical slices, the α-adrenergic component of the NE response in striatal slices is not dependent on endogenous adenosine. Finally, 6-FNE interactions with adenylate cyclase in striatal homogenates differ from those observed in the slice preparation. In homogenates, 6-FNE appears to directly stimulate adenylate through a D-1 receptor. D-1 receptor involvement in catecholamine responses in the striatal slice preparation, on the other hand, appears to minimal.
