Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters
Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters
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组蛋白变体 H3.3 的动力学及其与 H2A.Z 在增强子和启动子处的共调节
DOI：
10.4161/nucl.28067
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发表时间：
2014-01-01
期刊：
影响因子：
3.7
通讯作者：
Li, Guohong
中科院分区：
文献类型：
--
作者：
Chen, Ping;Wang, Yan;Li, Guohong
在真核生物中，基因组DNA由组蛋白分级包装成染色质。具有特定表观遗传修饰模式的基因组到染色质的特定组织对于转录调节、细胞命运决定和维持至关重要，其中组蛋白变体的掺入被描述为最关键的角色之一。组蛋白变体的多样性导致了染色质的结构可塑性，并突出了功能上不同的染色体结构域。在这里，我们重点研究了组蛋白变异体H3.3及其与H2A.Z在染色质增强子和启动子以及转录调控中的共同调节作用。
In eukaryotes, genomic DNA is hierarchically packaged into chromatin by histones. A defined organization of the genome into chromatin with specific patterns of epigenetic modifications is crucial for transcriptional regulation, cell fate determination, and maintenance, in which the histone variant incorporation has been characterized as one of the most key players. The diversity of histone variants results in structural plasticity of chromatin and highlights functionally distinct chromosomal domains. Here we focus on the role of histone variant H3.3 and its coregulation with H2A.Z in chromatin dynamics at enhancers and promoters and transcriptional regulation.